Our lab has not validated this product for in vivo application.
L9504
D-Luciferin
luminescent, ≥98% (HPLC), powder
Sinónimos:
(S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic acid, 4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid, Firefly Luciferin
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About This Item
Fórmula empírica (notación de Hill):
C11H8N2O3S2
Número de CAS:
Peso molecular:
280.32
Beilstein/REAXYS Number:
30484
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
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Nombre del producto
D-Luciferin, synthetic
biological source
synthetic
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 10 mg/mL, clear, colorless to faintly yellow
fluorescence
λex 328 nm; λem 532 nm in H2O
storage temp.
−20°C
SMILES string
OC(=O)[C@H]1CSC(=N1)c2nc3ccc(O)cc3s2
InChI
1S/C11H8N2O3S2/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16/h1-3,7,14H,4H2,(H,15,16)/t7-/m1/s1
Inchi Key
BJGNCJDXODQBOB-SSDOTTSWSA-N
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General description
D-Luciferin is a small molecule present abundantly in bioluminescent organisms. This molecule is sensitive to oxygen and light.[1]
Application
D-Luciferin has been used in determining luciferase activity by luciferase assay in mice[2] and Arabidopsis thaliana seeds.[3] It has also been used in measuring bioluminescence in neonatal rat ventricular cardiomyocytes.[4]
Substrate for firefly luciferase with a Km of approx 2 μM.
Biochem/physiol Actions
D-Luciferin uptake within the cells is regulated by the adenosine triphosphate (ATP)-binding cassette (ABC) transporter inhibitors like ATP-binding cassette transporter G2 (ABCG2)/ breast cancer resistance protein (BCRP) inhibitor fumitremorgin C. This substrate is oxidized by firefly luciferase that results in emitting a photon, which has the capability of passing through living tissues.[5]
Application
replaced by
Referencia del producto
Descripción
Precios
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Bioluminescence imaging (BLI) systems allows for high-sensitive and noninvasive monitoring of cell proliferation, activity of signaling pathways and protein-protein interactions in living tissues.
seMpai substrate is suitable for near-infrared BLI in biological experiments, offering high solubility for extended bioluminescent applications.
seMpai substrate is suitable for near-infrared BLI in biological experiments, offering high solubility for extended bioluminescent applications.
seMpai substrate is suitable for near-infrared BLI in biological experiments, offering high solubility for extended bioluminescent applications.
Chromatograms
application for HPLCapplication for HPLC-
Is this product suitable for injection into mice for in vivo applications after being dissolved in DMSO?
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