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I1286

Sigma-Aldrich

Icariin

≥94% (HPLC)

Sinónimos:

4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside

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About This Item

Fórmula empírica (notación de Hill):
C33H40O15
Número de CAS:
489-32-7
Peso molecular:
676.66
Número MDL:
MFCD00210516
Código UNSPSC:
12352205
ID de la sustancia en PubChem:
329815347
NACRES:
NA.25

Nivel de calidad

100

Ensayo

≥94% (HPLC)

color

light yellow to yellow

solubilidad

DMSO: 50 mg/mL, clear, colorless to dark yellow

aplicaciones

metabolomics
vitamins, nutraceuticals, and natural products

temp. de almacenamiento

room temp

cadena SMILES

COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2

InChI

1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

Clave InChI

TZJALUIVHRYQQB-XLRXWWTNSA-N

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Categorías relacionadas

Descripción general

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.

Aplicación

Icariin has been used:
  • in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats
  • to test its analgesic effects on lower back pain (LBP) in rats
  • as a potential treatment in osteoporosis condition in rats
  • to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes
  • as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells

Acciones bioquímicas o fisiológicas

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.
Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
WXBF3544V
WXBF2114V
WXBD8605V
WXBD2828V
MKCJ1712

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Xin Zhang et al.
Phytotherapy research : PTR, 28(4), 498-509 (2013-07-05)
Traditional Chinese medicines have been recommended for bone regeneration and repair for thousands of years. Currently, the Herba Epimedii and its multi-component formulation are the attractive native herbs for the treatment of osteoporosis. Icariin, a typical flavonol glycoside, is considered
Ying Pan et al.
Psychoneuroendocrinology, 38(1), 122-134 (2012-06-06)
Epidemiological evidence demonstrates the neuroendocrine link between stress, depression and diabetes. This study observed glucose intolerance of rats exposed to chronic unpredictable mild stress (CUMS) in oral glucose tolerance test (OGTT). CUMS procedure significantly up-regulated corticotropin-releasing factor (CRF)-related peptide urocortin
Lijuan Yang et al.
Journal of ethnopharmacology, 145(3), 715-721 (2012-12-25)
Epimedium brevicornum Maxim has long been used for the treatment of osteoporosis in China and other Asian countries. However, the mechanism behind the antiosteoporotic activity of this medicinal plant is not fully understood. The present study was designed to investigate
Jae-Wook Yoon et al.
Animal bioscience, 34(4), 546-557 (2020-08-12)
If fertilization does not occur within a specific period, the quality of unfertilized oocytes in the oviduct (in vivo aging) or in culture (in vitro aging) will deteriorate over time. Icariin (ICA), found in all species of Epimedium herbs, has
Wangkheirakpam Ramdas Singh et al.
European journal of pharmacology, 858, 172466-172466 (2019-06-21)
Icariin is a flavonoid from plant belonging to the genus Epimedium, commonly known as Horny goat weed or Yin Yang Huo. The compound possesses multiple biological activities which are associated with the modulation of many signalling pathways, like NF-κB, Erk-p38-JNK
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