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Key Documents

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H6647

Sigma-Aldrich

L-Histidinol dihydrochloride

≥98% (TLC)

Sinónimos:

β-Aminoimidazole-4-propanol dihydrochloride, (S)-2-Amino-3-(4-imidazolyl)propanol dihydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C6H11N3O · 2HCl
Número de CAS:
1596-64-1
Peso molecular:
214.09
Beilstein/REAXYS Number:
3914853
EC Number:
216-482-2
MDL number:
MFCD00078058
UNSPSC Code:
12352209
PubChem Substance ID:
24895755
NACRES:
NA.32

product name

L-Histidinol dihydrochloride, ≥98 (TLC)

Quality Level

200

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

198-201 °C (dec.) (lit.)

application(s)

cell analysis

SMILES string

Cl[H].Cl[H].N[C@H](CO)Cc1c[nH]cn1

InChI

1S/C6H11N3O.2ClH/c7-5(3-10)1-6-2-8-4-9-6;;/h2,4-5,10H,1,3,7H2,(H,8,9);2*1H/t5-;;/m0../s1

InChI key

FRCAFNBBXRWXQA-XRIGFGBMSA-N

Gene Information

human ... HRH1(3269)
mouse ... HRH1(15465)
rat ... HRH1(24448)

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Application

L-Histidinol dihydrochloride has been used:
  • as a reagent in urinary metabolite analysis
  • for making DT40 knockout cells, where cells were selected in 1mg/ml histidinol
  • for inducing amino acid deprivation in HepG2 cells

Biochem/physiol Actions

Precursor of histamine; reversible inhibitor of protein synthesis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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European journal of immunology, 50(3), 380-395 (2019-12-11)
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Under normal growth conditions the mammalian target of rapamycin complex 1 (mTORC1) negatively regulates the central autophagy regulator complex consisting of Unc-51-like kinases 1/2 (Ulk1/2), focal adhesion kinase family-interacting protein of 200 kDa (FIP200) and Atg13. Upon starvation, mTORC1-mediated repression
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