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H6291

Sigma-Aldrich

IL-1β human

HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

Sinónimos:

Interleukin-1β human, Lymphocyte activating factor, IL-1β

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About This Item

Número MDL:
MFCD00131399
Código UNSPSC:
12352202
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Interleukin-1β human, IL-1β, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture, endotoxin tested

origen biológico

human

Nivel de calidad

100

recombinante

expressed in HEK 293 cells

Ensayo

≥95% (SDS-PAGE)

Formulario

lyophilized powder

potencia

≤0.05 ng/mL EC50

calidad

endotoxin tested

mol peso

dimer 18-25 kDa (glycosylated)

envase

pkg of 10 μg

técnicas

cell culture | mammalian: suitable

impurezas

<1 EU/μg

Nº de acceso UniProt

P01584

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IL1B(3553)

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Acciones bioquímicas o fisiológicas

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cell lymphocytes, which then proliferate and secrete interleukin-2 (IL-2). IL-1 is released primarily from stimulated macrophages and monocytes, but has also been shown to be released from several other types and is thought to play a key role in inflammatory and immune responses. Other synonyms for IL-1 include: endogenous pyrogen (EP), mitogenic protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFM), B Cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF) The two closely related agents Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) share 62% homology in amino acid sequence and elicit nearly identical biological responses. IL-1α and IL-1β are both approximately 17 kDa with some heterogeneity in the amount of glycosylation.
Interleukin-1 activates T cell lymphocytes, which then proliferate and secrete interleukin-2 (IL-2). IL-1 is released primarily from stimulated macrophages and monocytes, but has also been shown to be released from several other types and is thought to play a key role in inflammatory and immune responses.

Forma física

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota de preparación

HumanKine Recombinant Human IL-1β, expressed in human HEK 293 cells, is a glycosylated monomer with a molecular mass of 18-25 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Nota de análisis

The activity is determined by the dose-dependent stimulation of the proliferation of mouse D10S cells.

Información legal

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCX1410
MKCW9150
MKCW0981
MKCS9179
MKCT7530

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Charles A Dinarello et al.
Current opinion in endocrinology, diabetes, and obesity, 17(4), 314-321 (2010-07-01)
To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta. Recent studies from animals, in-vitro cultures and clinical trials provide evidence that support a causative role for IL-1beta
J O R Hernandez et al.
Nature communications, 12(1), 6496-6496 (2021-11-13)
The lack of animal models for some human diseases precludes our understanding of disease mechanisms and our ability to test prospective therapies in vivo. Generation of kidney organoids from Tuberous Sclerosis Complex (TSC) patient-derived-hiPSCs allows us to recapitulate a rare
Daniela Guidone et al.
JCI insight (2022-10-12)
The fluid covering the surface of airway epithelia represents a first barrier against pathogens. The chemical and physical properties of the airway surface fluid are controlled by the activity of ion channels and transporters. In cystic fibrosis (CF), loss of

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