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H0266

Sigma-Aldrich

Hemoglobin A2, Ferrous Stabilized human

lyophilized powder

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About This Item

Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
eCl@ss:
42030116
NACRES:
NA.61
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

human

Nivel de calidad

Ensayo

97-100% (agarose gel electrophoresis)

Formulario

lyophilized powder

técnicas

immunofluorescence: suitable

idoneidad

suitable for electrophoresis and chromatography standard

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Información sobre el gen

human ... HBA2(3040)

Descripción general

Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3.[1] HBA2 is a minor hemoglobin component and comprises of two α and δ chains.[2]
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).

Aplicación

Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.[3]
Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile.[4] It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.[5]

Acciones bioquímicas o fisiológicas

Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.[2]

Envase

Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).

Reconstitución

When reconstituted with buffer, gives >90% ferrous hemoglobin.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Dominant β-thalassemia - a rare entity!
Rachna Khera et al.
Indian journal of pathology & microbiology, 55(3), 422-423 (2012-10-04)
Domenico Dell'Edera et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 26(5), 445-448 (2012-10-09)
This research, conducted on 1495 couples in preconceptional period, demonstrates how the study of globular resistance of erythrocytes (GRO) is not a first choice test and not useful as other more accurate tests to identify subjects with β-thalassemia trait. Instead
Alauddin Hafiza et al.
The Malaysian journal of pathology, 34(2), 161-164 (2013-02-22)
The capillary electrophoresis (CE) is a new system that utilizes the principle of electrokinetic separation of molecules in eight electrolyte buffer-filled silica capillaries. In this study, we established the normal ranges of haemoglobin A2 (HbA2) and haemoglobin F (HbF) levels
Stacy Colaco et al.
Clinica chimica acta; international journal of clinical chemistry, 413(19-20), 1705-1707 (2012-06-05)
An increased HbA2 level is the hallmark for identification of β thalassemia carriers. However, in some carriers the level of HbA2 is not typically elevated creating difficulties in making a diagnosis. We describe a family having an affected child referred
Hb Dartmouth (HBA2: c. 200T> C): An alpha2-globin gene associated with Hb H disease in one homozygous patient
Farashi S, et al.
Hemoglobin, 39(3), 152-155 (2015)

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