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GW22921

Sigma-Aldrich

Anti-ST8SIA1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

NP_003025.1

UniProt accession no.

Q92185

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ST8SIA1(6489)

Categorías relacionadas

General description

The previously assigned protein identifier Q6PZN5 has been merged into Q92185. Full details can be found on the UniProt database.

Immunogen

Immunogen Sequence: GI # 4506953, sequence 4-18
Synthetic peptide sequence of ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 1.

Application

Anti-ST8SIA1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

α-N-acetylneuraminide α-2,8-sialyltransferase is an enzyme encoded by the ST8SIA1 gene in humans. It acts as an oligosialyltransferase in a cellular context. ST8SIA1 gene encodes a ganglioside synthase and is susceptibile to diseases. The gene is found to be associated with Multiple sclerosis (MS).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

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Agata Steenackers et al.
Molecules (Basel, Switzerland), 17(8), 9559-9572 (2012-08-14)
Glycosphingolipids from the ganglio-series are usually classified in four series according to the presence of 0 to 3 sialic acid residues linked to lactosylceramide. The transfer of sialic acid is catalyzed in the Golgi apparatus by specific sialyltransferases that show
Sreeram V Ramagopalan et al.
Journal of neuroimmunology, 212(1-2), 142-144 (2009-05-12)
Multiple sclerosis (MS) is a complex trait with a significant genetic component. Recent work has implicated the ST8SIA1 gene, encoding a ganglioside synthase, in susceptibility to the disease, perhaps with a parent-of-origin effect. In this investigation of 1318 MS patients

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