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Key Documents

G8764

Sigma-Aldrich

Gc-globulin from human plasma

≥90% (SDS-PAGE), lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)

Sinónimos:

DBP, Group-Specific Component, Vitamin D Binding Protein

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About This Item

Número de CAS:
68476-36-8
MDL number:
MFCD00131143
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

human plasma

Quality Level

200

assay

≥90% (SDS-PAGE)

form

lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)

mol wt

~52 kDa

technique(s)

LC/MS: suitable

solubility

H2O: soluble 2 mg/mL

UniProt accession no.

P02774

storage temp.

−20°C

Gene Information

human ... GC(2638)

General description

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.
Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.

Application

Gc-globulin from human plasma has been used:
  • as a fluorescent probe for G-actin staining
  • as a fluorescent probe to monitor steady-state rate of actin filament disassembly
  • as a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)

Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions. It has been used to anlayze its glycosylation patterns.

Biochem/physiol Actions

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].

Preparation Note

Native Gc-globulin from human plasma

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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V F Rusiaev
Meditsinskaia tekhnika, (3)(3), 36-40 (1987-05-01)
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We have recently shown positive effects in the quality of life in autism and amyloid lateral sclerosis patients using a newly developed 25-OH vitamin D deglycosylated vitamin D binding protein complex (VitD~dgVDBP) by reducing oxidative stress. The question arises whether
David Palmer et al.
Internal medicine journal, 52(1), 89-94 (2020-10-12)
Free concentrations of highly protein bound hormones, such as cortisol and thyroxine, are unchanged in critical illness despite substantial decreases in total concentration. Total 25-hydroxyvitamin D (25(OH)D) concentration is decreased in critical illness, but the free concentration of 25(OH)D has
David Kessel et al.
Photochemistry and photobiology, 84(5), 1272-1276 (2008-06-03)
The proapoptotic effects of the Bcl-2 antagonist HA14-1 are believed to derive from its affinity for the hydrophobic groove on Bcl-2 and Bcl-x(L), thereby displacing proapoptotic factors, e.g. Bax and Bak. We have reported that HA14-1 promotes the efficacy of
Anders H Berg et al.
PloS one, 16(7), e0254158-e0254158 (2021-07-10)
Bioavailable 25-hydroxyvitamin D (25OHD) may be a better indicator of vitamin D sufficiency than total 25OHD. This report describes a novel assay for measuring serum bioavailable 25OHD. We developed an assay for 25OHD % bioavailability based on competitive binding of
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