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Merck
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Key Documents

F8190

Sigma-Aldrich

Fucoidan from Fucus vesiculosus

≥95%

Sinónimos:

Fucoidin

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About This Item

Número de CAS:
9072-19-9
MDL number:
MFCD00131109
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

algae (Fucus Vesiculosus)

Quality Level

200

assay

≥95%

form

powder

color

light yellow

useful pH range

5.0-11.0

solubility

water: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

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General description

Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.

Application

Fucoidan from Fucus vesiculosus has been to:
  • study the application of heparin red in detecting fucoidan
  • study its bioactivity as an antimicrobial agent
  • study its effects on advanced glycation end-products

Biochem/physiol Actions

Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation with subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified advanced glycation end product-protein phagocytosis
Shinichi H et al.
Scientific Reports, 8(1), 5901-5901 (2018)
Fanlu Wang et al.
Marine drugs, 19(4) (2021-04-04)
Fucoidans, sulfated polysaccharides extracted from brown algae, are marine products with the potential to modulate bone formation and vascularization processes. The bioactivity and safety of fucoidans are highly associated with their chemical structure, which may vary with algae species and
Bioactivity of Fucoidan as an Antimicrobial Agent in a New Functional Beverage
Poveda-Castillo et al.
Becker-Shaffer's Diagnosis and Therapy of the Glaucomas (2018)
Li-Mei Chen et al.
Scientific reports, 7(1), 11864-11864 (2017-09-21)
Low-molecular-weight Fucoidan (Oligo-Fucoidan) is a sulfated polysaccharide that has a variety of biological effects and has also been shown to have beneficial health effects. However, the molecular mechanisms underlying the therapeutic effects of Oligo-Fucoidan in patients with cancer remain unclear.
Jie Zhang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 130, 110534-110534 (2020-07-28)
Doxorubicin (DOX) is well-known for its potent antitumor activity but limited by its multiple and serious adverse effects. A major adverse effect is acute cardiotoxicity; yet, its mechanism has not been elucidated. Fucoidan is a multifunctional and nontoxic polysaccharide that
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