The F5631 is not tested for purity or to identify possible impurities. It is a crude fucoidan from Fucus vesiculosus.
F5631
Fucoidan from Fucus vesiculosus
Crude
Sinónimos:
Fucoidin
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About This Item
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Productos recomendados
biological source
algae (Fucus Vesiculosus)
Quality Level
form
powder
quality
Crude
color
light yellow to brown
solubility
H2O: 10 mg/mL, clear to hazy, faintly yellow to brownish-yellow
cation traces
Ca: ≤1%
Na: ≤ 8% (ICP)
storage temp.
room temp
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General description
Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.
Application
Fucoidan from Fucus vesiculosus may be used as a biological response modifier and as a potential therapeutic agent with a wide range of biological activities. It may be used to study its pharmacokinetics, safety, efficacy and methods of delivery as a potential anticancer, anti-immune and anti-inflammatory agent. Fucoidan may be used to assess its potential and formulations for tissue engineering applications.
Biochem/physiol Actions
Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation with subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.
Preparation Note
Prepared by a modification of the method of Black, W.A.P., et al., J. Sci. Food Agri., 3, 122 (1952).
Other Notes
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
Wiktoria Blaszczak et al.
Molecules (Basel, Switzerland), 23(12) (2018-12-14)
Fucoidans have been reported to exert anticancer effects with simultaneous low toxicity against healthy tissue. That correlation was observed in several cancer models, however, it has never been investigated in head and neck cancer before. To magnify the efficacy of
Celina Maria P Guerra Dore et al.
Carbohydrate polymers, 91(1), 467-475 (2012-10-10)
Fucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate
Suwaree Kitikiew et al.
Fish & shellfish immunology, 34(1), 280-290 (2012-12-04)
In this study, we examined the effect of fucoidan on the immune response of white shrimp Litopenaeus vannamei and its resistance against Vibrio alginolyticus infection. Fucoidan induced degranulation, caused changes in the cell morphology, and increased activation of prophenoloxidase (proPO)
Weihua Jin et al.
Carbohydrate polymers, 91(1), 1-6 (2012-10-10)
Seven fucoidans that differed only with respect to the average molecular weight and four fucoidans that differed with respect to both the molar ratio of fucose to galactose and the average molecular weight were obtained. The anticoagulant activities of these
Wei Wang et al.
Marine drugs, 10(12), 2795-2816 (2012-12-14)
Recently, the studies on the antiviral activities of marine natural products, especially marine polysaccharides, are attracting more and more attention all over the world. Marine-derived polysaccharides and their lower molecular weight oligosaccharide derivatives have been shown to possess a variety
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What is the purity of Product F5631, Fucoidan from Fucus vesiculosus?
1 answer-
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Is there information about the structure of Product F5631, Fucoidan from Fucus vesiculosus?
1 answer-
In general, fucoidin is a branched polymer of L-fucose monosulfate joined predominately by 1,2 linkages. Fucoidin is also known in the literature as fucan. The properties are discussed further by Bernardi and Springer in J. Biol. Chem, 237, 75-80 (1962); the title of the article is "Properties of highly purified fucan".
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What is the solubility of Product F5631, Fucoidan from Fucus vesiculosus?
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The F5631 is water-soluble. It is tested for solublity in water at 10mg/mL; this yields a clear to hazy, yellow to amber solution.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the molecular weight of Product F5631, Fucoidan from Fucus vesiculosus?
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The molecular weight of the F5631 is assayed on a lot-by-lot basis. The molecular weight will be reported on the certificate of analysis for each lot of product.
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