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Merck

D3447

Sigma-Aldrich

Doxycycline hydrochloride

Sinónimos:

2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aR,5S,5aR,6R,12aS)-

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About This Item

Fórmula empírica (notación de Hill):
C22H24N2O8 · HCl
Número de CAS:
Peso molecular:
480.90
MDL number:
UNSPSC Code:
51284028
NACRES:
NA.85
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biological source

synthetic

Quality Level

form

powder

color

yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites

mode of action

protein synthesis | interferes

storage temp.

−20°C

InChI

1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1

InChI key

VLUQVUWDECWBTL-UQVCFKGQSA-N

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General description

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.

Application

Doxycycline hydrochloride has been used for the induction of shRNA expression and induction of expression vectors.[1][2][3]

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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John D Chan et al.
Nature communications, 8(1), 1910-1910 (2017-12-07)
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David van Dijk et al.
Cell, 174(3), 716-729 (2018-07-03)
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Claire-Anne G et al.
Neuroscience, 339 (2016)
Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress
Beate H et al.
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Questions

1–2 of 2 Questions  
  1. IS DOXYCYCLINE HYDROCHLORIDE (D3447) SOLUBLE IN WATER 50 MG/ML?

    1 answer
    1. This product is soluble in water at 50 mg/ml.

      Helpful?

  2. What is the best way to solubilize the product for cell culture and animal use?

    1 answer
    1. This product has not been tested for use in cell culture. However, product D5207 is a cell culture tested Doxycycline Hyclate. The Hyclate and the Hydrochloride salt forms are soluble in water at roughly equal rates. For dosing purposes, the unique molecular weight of each must be considered. Please see the link below to the product data sheet for the cell culture version of this product. This information offered in this document may be applied to the D3447:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/297/d5207dat.pdf

      Note that neither of these products are sterile. Prepared stock solutions must be filter sterilized prior to adding them to the culture medium.

      Helpful?

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