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Merck
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Key Documents

D0444

Sigma-Aldrich

DT-2 trifluoroacetate salt

≥95% (HPLC), film

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About This Item

Fórmula empírica (notación de Hill):
C122H223N53O23 · xC2HF3O2
Peso molecular:
2800.42 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

200

assay

≥95% (HPLC)

form

film

composition

Peptide content, ≥60%

color

colorless to white

solubility

H2O: 0.5 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

Amino Acid Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-NH2

Biochem/physiol Actions

Cell permeable cGMP protein kinase (PKG) inhibitor

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Mark S Taylor et al.
Molecular pharmacology, 65(5), 1111-1119 (2004-04-23)
Cyclic GMP-dependent protein kinase (PKG) serves as an important physiological regulator of vascular reactivity and tone. However, available inhibitors of PKG have exhibited variable effects in intact tissue, hindering the elucidation of the functional role of PKG in blood vessels.
W R Dostmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14772-14777 (2000-12-20)
Arrays of octameric peptide libraries on cellulose paper were screened by using (32)P-autophosphorylated cGMP-dependent protein kinase Ialpha (cGPK) to identify peptide sequences with high binding affinity for cGPK. Iterative deconvolution of every amino acid position in the peptides identified the
Christin Christensen et al.
Stem cells and development, 15(5), 647-654 (2006-11-16)
Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh

Artículos

PKA & PKG

Our offers many products related to PKA & PKG for your research needs.

PKA & PKG

Our offers many products related to PKA & PKG for your research needs.

PKA & PKG

Our offers many products related to PKA & PKG for your research needs.

PKA & PKG

Our offers many products related to PKA & PKG for your research needs.

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