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C9873

Sigma-Aldrich

CPTH2

≥98% (HPLC), powder

Sinónimos:

Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone

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About This Item

Fórmula empírica (notación de Hill):
C14H14ClN3S
Número de CAS:
357649-93-5
Peso molecular:
291.80
Número MDL:
MFCD02307488
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329775211
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to beige

solubilidad

DMSO: >10 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Clc1ccc(cc1)-c2csc(N\N=C3\CCCC3)n2

InChI

1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)

Clave InChI

YYTHPXHGWSAKIZ-UHFFFAOYSA-N

Categorías relacionadas

Descripción general

CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 and H4. CPTH2 promotes apoptosis in lymphoma cell lines. It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.

Aplicación

CPTH2 has been used for the inhibition of histone acetyltransferase in cortical cultures, bud cells and natural killer T cells (iNKT).

Acciones bioquímicas o fisiológicas

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network.
CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

Características y beneficios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000406907
0000406907
125M4615V
082M4607V
069K46162

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SAHA ≥98% (HPLC)

Sigma-Aldrich

SML0061

SAHA

Sodium butyrate ≥98.5% (GC)

Sigma-Aldrich

B5887

Sodium butyrate

A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4?-chlorophenyl) thiazol-2-yl) hydrazone
Chimenti F, et al.
Journal of Medicinal Chemistry, 52(2), 530-536 (2008)
The thiazole derivative CPTH6 impairs autophagy
Ragazzoni Y, et al.
Cell Death & Disease, 4(3), e524-e524 (2013)
Epigenetic profiling reveals a developmental decrease in promoter accessibility during cortical maturation in vivo
Venkatesh I, et al.
Neuroepigenetics, 8, 19-26 (2016)
CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells
Trisciuoglio D, et al.
Clinical Cancer Research, 18(2), 475-486 (2012)
Interactive histone acetylation and methylation in regulating transdifferentiation-related genes during tunicate budding and regeneration
Shibuya M, et al.
Developmental Dynamics, 244(1), 10-20 (2015)
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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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