C8999

Calpeptin

≥98% (HPLC)

• Sinónimos: N-Benzyloxycarbonyl-L-leucylnorieucinal, Z-Leu-Nle-CHO
• Fórmula empírica (notación de Hill): C₂₀H₃₀N₂O₄
• Número de CAS: 117591-20-5
• Peso molecular: 362.46
• Número MDL: MFCD00155623
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329775192
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 15 mg/mL, clear
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
• InChI: 1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1
• Clave InChI: PGGUOGKHUUUWAF-ROUUACIJSA-N

Descripción

Descripción general

Calpeptin (Z-Leu-nLeu-H) is a cell permeable, peptide aldehyde inhibitor. It is more sensitive to calpain I compared to other inhibitors, such as Z-Leu-Met-H and leupeptin.[1] Calpeptin stimulates neurite elongation in differentiating pheochromocytoma (PC12) cells.[2] Calpeptin decreases microgliosis, astrogliosis, axonal damage and neuron and oligodendrocyte death in experimental autoimmune encephalomyelitis (EAE) spinal cord. Therefore, it can be considered as a potent therapeutic for treating EAE and multiple sclerosis (MS).[3]

Aplicación

Calpeptin has been used as a calpain inhibitor.[4]

Acciones bioquímicas o fisiológicas

Calpeptin is a calpain inhibitor and rho kinase activator.

Calpeptin is a rho kinase activator and an inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in apoptosis, long-term potentiation in neurons, and cell cycle progression.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable