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Merck

C5678

Sigma-Aldrich

Carboxymethylcellulose sodium salt

low viscosity

Sinónimos:

Sodium carboxymethylcellulose

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About This Item

Número de CAS:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25
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biological source

synthetic (organic)

Quality Level

form

powder

color

light yellow

useful pH range

(20 °C, 10 g/L, 68 °F neutral)

viscosity

50-200 cP, 4 % in H2O(25 °C)

mp

> 300.05  °C ((> 572.09 °F ))

solubility

water: soluble

cation traces

Na: 6.5-9.5%

storage temp.

room temp

SMILES string

[Na].OC(C(O)C(O)C=O)C(O)CO.OC(=O)C

InChI

1S/C6H12O6.C2H4O2.Na/c7-1-3(9)5(11)6(12)4(10)2-8;1-2(3)4;/h1,3-6,8-12H,2H2;1H3,(H,3,4);

InChI key

DPXJVFZANSGRMM-UHFFFAOYSA-N

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General description

This product is a low viscosity carboxymethylcellulose (CMC); the viscosity of a 4% solution in water at 25 oC is 50-200 centipoise (cps). The viscosity is both concentration and temperature dependent. As the temperature increases, the viscosity decreases. As the concentration increases, the viscosity increases. Low, medium and high viscosity carboxymethylcellulose (CMC) are all used as suspending agents. Low viscosity CMC is usually used in "thin" aqueous solutions. Medium viscosity CMC is used to make solutions that look like a syrup. High viscosity CMC is used to make a mixture, which resembles a cream or lotion.

Application

Soluble carboxymethylcelluloses (CM-cellulose; CMC) available in varying viscosities are used as viscosity modifiers (thickeners) to stabilize emulsions and as a chemical dispersants of oils and other carbon structures such as nanotubes. CMCs are used in the development of biostructures such as biofilms, emulsions and nanoparticles for drug delivery. Carboxymethylcellulose, low viscosity, may be used to make solutions the consistency of "thin" aqueous solutions.[1]

Preparation Note

The product is soluble in water (40 mg/mL).The key to dissolving carboxymethylcellulose is to add the solid carefully to the water so that it is well dispersed (well-wetted). Adding the solid in portions may be necessary. Adding water to the dry solid produces a "clump" of solid that is very difficult to dissolve; the solid must be added to the water. Stir gently or shake intermittently; do not stir constantly with a magnetic stirring bar. High heat is not needed and may actually slow down the solubilization process. A mixing device, such as an impeller-type agitator which produces a vortex, would allow the powder to be drawn into the liquid, but it may produce some shearing.

Under normal conditions, the effect of temperature on solutions of this product is reversible, so slight temperature variation has no permanent effect on viscosity. However, long periods of heating CMC solutions at high temperatures (autoclaving) will degrade the product and permanently reduce viscosity. CMC is therefore very difficult to sterilize. γ-Irradiation, like heating, will degrade CMC. High viscosity CMC is more adversely affected by autoclaving and irradiation than is low viscosity CMC. Filtering CMC solutions tends to leave a gel behind because the material is fibrous, so solutions cannot be sterile filtered.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Certificados de análisis (COA)

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R Farenzena et al.
Journal of animal physiology and animal nutrition, 101(5), 1057-1066 (2016-07-28)
Two in vivo digestibility trials with sheep were conducted to identify the minimum period length of feeding a new diet to obtain reproducible values of nutritional variables onward and the minimum length of collection period as to obtain maximal precision for
Shigenobu Mitsuzawa et al.
Scientific reports, 7(1), 16320-16320 (2017-11-28)
The glycoside hydrolase family 7 (GH7) member cellobiohydrolase (CBH) is a key enzyme that degrades crystalline cellulose, an important structural component of plant cell walls. As GH7 CBH is a major component in the enzyme mixture used to degrade biomass
C Philippeau et al.
Journal of dairy science, 100(4), 2637-2650 (2017-02-06)
This study investigated the effects of bacterial direct-fed microbials (DFM) on ruminal fermentation and microbial characteristics, methane (CH
Tim Wartewig et al.
Nature, 552(7683), 121-125 (2017-11-17)
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells and are frequently characterized by genetic gain-of-function variants in T cell receptor (TCR) signalling molecules. Although
Georg Geisberger et al.
Small (Weinheim an der Bergstrasse, Germany), 7(19), 2808-2814 (2011-09-29)
Polyoxometalate/carboxymethyl chitosan nanocomposites with an average diameter of 130 nm are synthesized and labeled with fluorescein isothiocyanate (FITC) for a combined drug-carrier and cellular-monitoring approach. [Eu(β(2) -SiW(11) O(39) )(2) ](13-) /CMC nanospheres as a representative example do not display cytotoxicity

Questions

1–5 of 5 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is the carboxymethycelluose sterile?

    1 answer
    1. This product is not sterile.

      Helpful?

  4. I want to ask the degree of substitution of this CMC (C5678-500G). Thanks in advance.

    1 answer
    1. As mention on the Product Specification Sheet, the acceptable range / quality specification for Degree of Substitution is 0.65 - 0.90 carboxymethyl groups per anhydroglucose unit.

      Helpful?

  5. I want to know the molecualr weight of the Carboxymethylcellulose sodium salt low viscosity (C5678-500G)

    1 answer
    1. The molecular weight is not determined for each lot, however, historical information indicates a molecular weight of approximately 90 kDa.

      Helpful?

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