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A3940

Sigma-Aldrich

1-Aminobenzotriazole

greener alternative

≥98% (TLC), powder, cytochrome P450 inhibitor

Sinónimos:

1-Benzotriazolamine, ABT

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About This Item

Fórmula empírica (notación de Hill):
C6H6N4
Número de CAS:
1614-12-6
Peso molecular:
134.14
Beilstein:
607843
Número MDL:
MFCD00132902
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278226
NACRES:
NA.77

Nombre del producto

1-Aminobenzotriazole,

Ensayo

≥98% (TLC)

Nivel de calidad

200

Formulario

powder

puntuación de productos alternativos más sostenibles

old score: 93
new score: 46
Find out more about DOZN™ Scoring

características de los productos alternativos más sostenibles

Waste Prevention
Safer Solvents and Auxiliaries
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

81-84 °C (lit.)

solubilidad

ethanol: 49-51 mg/mL, clear, pale yellow to yellow

categoría alternativa más sostenible

, Re-engineered

cadena SMILES

Nn1nnc2ccccc12

InChI

1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2

Clave InChI

JCXKHYLLVKZPKE-UHFFFAOYSA-N

Información sobre el gen

human ... CYP1A2(1544)

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Categorías relacionadas

Descripción general

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Aplicación

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Acciones bioquímicas o fisiológicas

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.
Suicide inhibitor of cytochrome P450 and chloroperoxidase.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000420467
0000420467
0000410697
0000410697
0000401293

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M Lizeth Orozco Morales et al.
iScience, 25(1), 103571-103571 (2022-01-06)
Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter
Effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells: a novel mechanism for the ?time window theory? of menopausal hormone therapy
Zhu C, et al.
Atherosclerosis, 215(2), 294-300 (2011)
Ailette Prieto et al.
Bioresource technology, 102(23), 10987-10995 (2011-09-23)
More than 90% of the antibiotics ciprofloxacin (CIPRO) and norfloxacin (NOR) at 2 mg L(-1) were degraded by Trametes versicolor after 7 days of incubation in malt extract liquid medium. In in vitro assays with purified laccase (16.7 nkat mL(-1))
Congli Zhu et al.
Atherosclerosis, 215(2), 294-300 (2011-02-09)
To investigate the effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells (VSMCs) and the underlying mechanisms. VSMCs of passage 2-3 cultured from young (2 months) and old (18 months) female SD rats were induced into premature
Shinji Shimizu et al.
Archives of toxicology, 85(4), 347-353 (2010-09-28)
We investigated hepatotoxicity induced by ticlopidine (TIC) in glutathione (GSH)-depleted rats by pre-treatment of a well-known GSH synthesis inhibitor, L-buthionine-S,R-sulfoxinine (BSO). Although sole administration of either TIC or BSO showed no signs of hepatotoxicity, combined administration of TIC with BSO
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