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A0550

Sigma-Aldrich

Ala-Gln

≥98% (HPLC)

Sinónimos:

Alanyl-glutamine, Glutamine-S

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About This Item

Fórmula empírica (notación de Hill):
C8H15N3O4
Número de CAS:
39537-23-0
Peso molecular:
217.22
Número MDL:
MFCD00133046
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
24890433
NACRES:
NA.26
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Ala-Gln, ≥98% (HPLC)

Nivel de calidad

200

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to off-white

cadena SMILES

NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

InChI

1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1

Clave InChI

HJCMDXDYPOUFDY-WHFBIAKZSA-N

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Aplicación

L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture as alternative delivery forms of stabilized L-glutamine. The primary advantage of using L-alanylglutamine in place of L-glutamine is that it reduces the level of ammonia generated during cell culture.[1][2]

Acciones bioquímicas o fisiológicas

Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo.[3][4] Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro.[5]

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000417442
0000417418
0000415722
0000415747
0000415722

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Ala-Ala

Sigma-Aldrich

A9502

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Ala-Gly

Sigma-Aldrich

A0878

Ala-Gly

L-Glutamina BioUltra, ≥99.5% (NT)

Sigma-Aldrich

49419

L-Glutamina

Gly-Tyr

Sigma-Aldrich

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Gly-Tyr

A Christie et al.
Biotechnology and bioengineering, 64(3), 298-309 (1999-07-09)
Although glutamine is a major carbon source for mammalian cells in culture, its chemical decomposition or cellular metabolism leads to an undesirable excess of ammonia. This limits the shelf-life of glutamine-supplemented media and may reduce the cell yield under certain
John D Biggers et al.
Reproductive biomedicine online, 9(1), 59-69 (2004-07-20)
A comparison of the effects of replacing L -glutamine with either glycyl-L-glutamine or alanyl-L-glutamine in a KSOM-type medium on the development of mouse preimplantation embryos in vitro has been made. Alanyl-L-glutamine has no significant effect on the rates of blastocyst
J Mühling et al.
Amino acids, 22(1), 39-53 (2002-05-25)
The objective of this study was to determine the effects of arginine, L-alanyl-L-glutamine (Ala-Gln) or taurine on polymorphonuclear leucocyte (PMN) free amino acid profiles, superoxide anion (O2-) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase activity (MPO). Arginine led to
G Biolo et al.
Nutrition (Burbank, Los Angeles County, Calif.), 13(9 Suppl), 52S-57S (1997-09-18)
The metabolic response to trauma and sepsis involves an increased loss of body proteins. Specific sites of changes of protein and amino acid metabolism have been identified. In skeletal muscle, the rate of proteolysis is accelerated greatly. The rate of
D E Johns et al.
Cells, tissues, organs, 185(4), 246-257 (2007-06-26)
The temporomandibular joint (TMJ) is extremely important for activities like eating and talking, which can become painful and difficult for patients with TMJ dysfunction. Tissue engineering is a potential alternative to current surgical interventions through replacement of diseased or injured
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