Inosine-5′-monophosphate (5′-IMP) may be used as a substrate to study the activity, specificity and kinetics of inosine 5′-monophosphate dehydrogenase (IMPDH) EC 1.1.1.205, the rate limiting enzyme for the formation of GMP and the guanine nucleotide pool.
Acciones bioquímicas o fisiológicas
Inosine monophosphate, or inosinic acid, is the ribonucleotide of hypoxanthine and the first nucleotide formed during purine synthesis.
International immunopharmacology, 10(1), 91-97 (2009-10-21)
Inosine 5'-monophosphate dehydrogenase (IMPDH) inhibition is a critical target in solid organ transplantation, and the development of mycophenolate mofetil (MMF) represents a major advance in transplant medicine. In this study, the in vitro and in vivo pharmacological effects of BMS-566419
Current medicinal chemistry, 18(13), 1909-1918 (2011-04-27)
Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the first committed step of guanosine 5'-monophosphate (GMP) biosynthesis, and thus regulates the guanine nucleotide pool, which in turn governs proliferation. Human IMPDHs are validated targets for immunosuppressive, antiviral and anticancer drugs, but as yet
Therapeutic drug monitoring, 33(2), 200-208 (2011-02-12)
There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) have been associated with a lower response rate and an increased risk of adverse events. In this study, the
Food science of animal resources, 40(3), 338-349 (2020-05-20)
The effects of organic Zn-L-selenomethionine (Zn-L-SeMet) at 0.3 ppm on carcass composition, meat characteristics, fatty acid composition, glutathione peroxidase activity, and ribonucleotide content were compared against the commercial inorganic sodium selenite (Na-Se) and the combination of the two, in commercial
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