27840

Corticosterone

≥98.5% (HPLC)

• Sinónimos: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Fórmula empírica (notación de Hill): C₂₁H₃₀O₄
• Número de CAS: 50-22-6
• Peso molecular: 346.46
• Beilstein: 2339601
• Número CE: 200-019-6
• Número MDL: MFCD00037715
• Código UNSPSC: 12352211
• ID de la sustancia en PubChem: 57648276
• NACRES: NA.77

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 200
• Ensayo: ≥98.5% (HPLC)
• Formulario: powder or crystals
• actividad óptica: [α]20/D +223±3°, c = 1% in ethanol
• mp: 179-183 °C (lit.); 179-183 °C
• grupo funcional: ketone
• cadena SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Clave InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Información sobre el gen: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Descripción

Descripción general

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

Aplicación

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Acciones bioquímicas o fisiológicas

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota de preparación

Corticosterone is soluble in chloroform and ethanol.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves