14370

Bilirrubina

purum, ≥95.0% (UV)

• Sinónimos: Bile pigment, Hemetoidin
• Fórmula empírica (notación de Hill): C₃₃H₃₆N₄O₆
• Número de CAS: 635-65-4
• Peso molecular: 584.66
• Beilstein/REAXYS Number: 74376
• EC Number: 211-239-7
• MDL number: MFCD00005499
• UNSPSC Code: 12352202
• PubChem Substance ID: 57647150
• NACRES: NA.25

Propiedades

• grade: purum
• Quality Level: 100
• assay: ≥95.0% (UV)
• form: powder
• ign. residue: ≤0.5%
• SMILES string: CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C
• InChI: 1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
• InChI key: BPYKTIZUTYGOLE-IFADSCNNSA-N

Descripción

General description

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.

Application

Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins.

Biochem/physiol Actions

Más del 99 % de la bilirrubina total es transportada como un conjugado con la albúmina. Niveles anormalmente elevados de bilirrubina pueden causar un daño neurológico grave, pero niveles levemente elevados están vinculados a la protección frente al estrés oxidativo.

Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.

Analysis Note

λ_max. ∼453 nm, mol. absorption >56100 (chloroform)

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)