14202
Diisopropyl-fluorophosphatase
≥30 U/mg
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About This Item
Productos recomendados
biological source
fermentation/recombinant
Quality Level
form
lyophilized solid
specific activity
≥30 U/mg
storage temp.
−20°C
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Unit Definition
One unit corresponds to the amount of enzyme which hydrolyzes 1 μmol diisopropyl fluorophosphate per minute at pH 8.1 and 22 °C
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
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Marc-Michael Blum et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 63(Pt 1), 42-45 (2006-12-22)
The enzyme diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris is capable of decontaminating a wide variety of toxic organophosphorus nerve agents. DFPase is structurally related to a number of enzymes, such as the medically important paraoxonase (PON). In order to investigate
Dragomir I Draganov
Chemico-biological interactions, 187(1-3), 370-372 (2010-02-04)
Serum paraoxonase (PON1) is well recognized for its ability to hydrolyze arylesters, toxic oxon metabolites of organophosphate insecticides and nerve agents. PON1 is a member of gene family including also PON2 and PON3; however, the later two enzymes have very
Marc-Michael Blum et al.
Journal of the American Chemical Society, 128(39), 12750-12757 (2006-09-28)
A wide range of organophosphorus nerve agents, including Soman, Sarin, and Tabun is efficiently hydrolyzed by the phosphotriesterase enzyme diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris. To date, the lack of available inhibitors of DFPase has limited studies on its mechanism.
T Wille et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(3), 1026-1031 (2009-12-08)
Developing improved medical countermeasures against chemical warfare agents (nerve agents) is urgently needed but time-consuming and costly. Here we introduce a robot-assisted liquid handling system with warming, cooling and incubating facilities to screen the detoxifying properties of biological and chemical
Marco Melzer et al.
Journal of the American Chemical Society, 131(47), 17226-17232 (2009-11-10)
Diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris is an efficient and robust biocatalyst for the hydrolysis of a range of highly toxic organophosphorus compounds including the nerve agents sarin, soman, and cyclosarin. In contrast to the substrate diisopropyl fluorophosphate (DFP) the
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