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Merck

07188

Sigma-Aldrich

Lithium mupirocin

≥95.0% (HPLC)

Sinónimos:

9-((E)-4-{(2S,3R,4R,5S)-3,4-Dihydroxy-5-[(2S,3S)-3-((1S,2S)-2-hydroxy-1-methyl-propyl)oxiranylmethyl]tetrahydro-pyran-2-yl}-3-methyl-but-2-enoyloxy)nonanoic acid lithium salt, Pseudomonic acid A lithium salt

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About This Item

Fórmula empírica (notación de Hill):
C26H43LiO9
Número de CAS:
Peso molecular:
506.56
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85

Quality Level

assay

≥95.0% (HPLC)

form

powder

color

white to off-white

antibiotic activity spectrum

Gram-positive bacteria

mode of action

protein synthesis | interferes

SMILES string

[Li+].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]2CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)[C@H](O)[C@@H]2O

InChI

1S/C26H44O9.Li/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27;/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29);/q;+1/p-1/b16-13+;/t17-,18-,19-,20-,21-,24+,25-,26-;/m0./s1

InChI key

XFIKMPRBSORKQP-JATHGWPISA-M

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Application

Lithium mupirocin as been used to study mupirocin resistance in staphylococcus aureus and in mycoplasma susceptibility studies .

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non Combustible Solids

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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P C Hannan
Journal of medical microbiology, 47(12), 1115-1122 (1998-12-18)
The susceptibilities of 40 strains of various Mycoplasma species to 10 classes of antimicrobial agents were compared in vitro by a broth microdilution method. The strains tested comprised 20 strains of four AIDS-associated species--M. penetrans (1 strain), M. fermentas (5
J Gilbart et al.
Antimicrobial agents and chemotherapy, 37(1), 32-38 (1993-01-01)
Mupirocin resistance in Staphylococcus aureus results from changes in the target enzyme, isoleucyl-tRNA synthetase (IRS). Twelve strains of S. aureus comprising four susceptible (MICs < or = 4 micrograms/ml), four intermediate level-resistant (MICs between 8 and 256 micrograms/ml), and four
Miranda M L van Rijen et al.
PloS one, 7(8), e43065-e43065 (2012-08-24)
A multi centre double-blind randomised-controlled trial (M-RCT), carried out in the Netherlands in 2005-2007, showed that hospitalised patients with S. aureus nasal carriage who were treated prophylactically with mupirocin nasal ointment and chlorhexidine gluconate medicated soap (MUP-CHX), had a significantly
Christine H Smith et al.
Canadian family physician Medecin de famille canadien, 58(12), 1350-1352 (2012-12-18)
I see otherwise healthy children in my practice with recurrent staphylococcal skin infections. While I am comfortable with managing each acute infection, what can be done to eradicate Staphylococcus aureus and reduce the chance of recurrent infections? Staphylococcus aureus skin
Joshua Jervis-Bardy et al.
The Laryngoscope, 122(10), 2148-2153 (2012-08-07)
Chronic rhinosinusitis (CRS) recalcitrant to surgery is a frustrating clinical entity. Recently, mupirocin sinonasal rinses have been suggested as an efficacious treatment alternative in these patients where Staphylococcus aureus infection is demonstrated. To our knowledge, how best to treat this

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