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Merck
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Key Documents

Y0000226

Moxonidine

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine

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About This Item

Fórmula empírica (notación de Hill):
C9H12ClN5O
Número de CAS:
75438-57-2
Peso molecular:
241.68
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

moxonidine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C9H12ClN5O/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9/h3-4H2,1-2H3,(H2,11,12,15)

InChI key

WPNJAUFVNXKLIM-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Moxonidine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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P Ernsberger
Journal of cardiovascular pharmacology, 35(7 Suppl 4), S27-S41 (2001-05-11)
The I1-imidazoline receptor is a novel neurotransmitter receptor found mainly in the brainstem, adrenal medulla and kidney. The actions of moxonidine are described at the level of individual biomolecules, cells, tissues, organs and finally with integrative functions. The receptor functions
Angelita Maria Stabile et al.
Life sciences, 88(11-12), 493-503 (2011-02-01)
Heart failure is a progressive deterioration in heart function associated with overactivity of the sympathetic nervous system. The benefit of inhibition of sympathetic activity by moxonidine, a centrally acting imidazoline receptor agonist, was questioned based on the outcome of a
Scintigraphic diagnosis of Erdheim-Chester disease.
Hans Balink et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(16), e470-e472 (2011-03-23)
Jun-Feng Peng et al.
Cardiovascular research, 89(2), 473-481 (2010-09-11)
The depressor action of the centrally antihypertensive drug moxonidine has been attributed to activation of I(1)-imidazoline receptor in the rostral ventrolateral medulla (RVLM). The objective of this study was to determine the role of the γ-aminobutyric acid (GABA) mechanisms in
B N Prichard et al.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 15(1), S47-S55 (1997-01-01)
Imidazoline I1-receptor agonism represents a new mode of antihypertensive action to inhibit peripheral alpha-adrenergic tone by a central mechanism. Adrenaline, noradrenaline and renin levels are reduced, a finding consistent with central inhibition of sympathetic tone. Acute haemodynamic studies indicate that
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