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S9876

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Sulfathiazole

Sulfathiazole

Sinónimos:

2-Sulfanilamidothiazole, 4-Amino-N-(2-thiazolyl)benzenesulfonamide, N1-(2-Thiazolyl)sulfanilamide

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About This Item

Fórmula empírica (notación de Hill):
C9H9N3O2S2
Número de CAS:
72-14-0
Peso molecular:
255.32
Beilstein/REAXYS Number:
226178
EC Number:
200-771-5
MDL number:
MFCD00005319
UNSPSC Code:
41116107
PubChem Substance ID:
329824636
NACRES:
NA.24
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grade

analytical standard

Quality Level

100

agency

EPA 1694

form

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

200-202 °C (lit.)

application(s)

clinical testing

SMILES string

Nc1ccc(cc1)S(=O)(=O)Nc2nccs2

InChI

1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)

InChI key

JNMRHUJNCSQMMB-UHFFFAOYSA-N

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General description

Sulfathiazole is a broad-spectrum antibacterial drug,[1] belonging to the class of sulfonamides, used in veterinary and human medication for the treatment of infections. It is also involved in promoting growth of livestock and fish.[2]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfathiazole is used as an analytical reference standard for the quantification of the analyte in meat,[3][2] and honey[1] samples using different chromatography techniques.

Biochem/physiol Actions

Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000355783
0000355783
0000297702
0000297702
0000203142

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Determination of sulfonamides in meat by liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry
Kim H-D, et al.
Bull. Korean Chem. Soc., 23(11), 1590-1594 (2002)
Comparison of separation conditions and ionization methods for the liquid chromatography?mass spectrometric determination of sulfonamides
Kim H-D and Lee WD
Journal of Chromatography A, 984(1), 153-158 (2003)
Quantitative LC/MS-MS determination of sulfonamides and some other antibiotics in honey
Kaufmann A, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 85(4), 853-860 (2002)
T Lotti et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 66(7), 1519-1526 (2012-08-07)
The feasibility of anaerobic ammonium oxidation (anammox) process to treat wastewaters containing antibiotics and heavy metals (such as the liquid fraction of the anaerobically digested swine manure) was studied in this work. The specific anammox activity (SAA) was evaluated by
Mi-Kyung Yun et al.
Science (New York, N.Y.), 335(6072), 1110-1114 (2012-03-03)
The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have severely compromised the usefulness of these drugs. We report structural, computational, and mutagenesis studies on the catalytic
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    • Review 1
    • Votes 2
    2 out of 5 stars.

    Required extra work

    Needed to be recrystallized - MS showed contamination with Na.

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for your review. This product is designated for research and laboratory use and undergoes basic qualtiy control testing. The minimum purity of any given lot will be 98% by HPLC. We do not further identify the impurities nor do we set minimum specifications on any potential contaminant. It is possible there there are trace amounts of residual salts and/or solvents which may interfere with more sensitive applications. We encourage customers who experience problems with our products to call or email us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.

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