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Merck

PHR1402

Supelco

Phenoxybenzamine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Phenoxybenzamine hydrochloride, N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C18H22ClNO · HCl
Número de CAS:
Peso molecular:
340.29
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to USP 1526007

API family

phenoxybenzamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

Inchi Key

VBCPVIWPDJVHAN-UHFFFAOYSA-N

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General description

Phenoxybenzamine Hydrochloride is an important drug belonging to the class of β-chloroethylamine drugs. It functions as an α-blocker by binding to α-adrenoreceptors, located on vascular smooth muscles and stops the influence of sympathetic nerves on blood vessels. It is widely used in the treatment of hypertension, benign prostatic hyperplasia and hypoplastic left heart syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Phenoxybenzamine Hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and chemiluminescence techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Calmodulin antagonist; α-adrenoceptor antagonist.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA2196 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Visite la Librería de documentos

Chiral aziridine ring opening: facile synthesis of (R)-mexiletine and (R)-phenoxybenzamine hydrochloride
Viswanadh N, et al.
Tetrahedron Letters, 56(38), 5269-5271 (2015)
Sensitive chemiluminescence determination of phentolamine mesylate and phenoxybenzamine hydrochloride based on K3Fe (CN) 6-H2O2-fluorescein
Xing L, et al.
Journal of Luminescence, 137(38), 162-167 (2013)
A facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method
Nikalje MD, et al.
Tetrahedron Asymmetry, 21(23), 2825-2829 (2010)
Quantitative gas chromatographic determination of azapetine and phenoxybenzamine in pharmaceutical preparations
Silvestri S and Taponeco G
Journal of Chromatography A, 37(38), 200-204 (1968)
Phenoxybenzamine and phenoxybenzamine hydrochloride.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 24, 185-194 (1980-01-01)

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