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Merck

PHR1046

Supelco

Ethylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Monoethylene glycol, 1,2-Ethanediol

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About This Item

Fórmula lineal:
HOCH2CH2OH
Número de CAS:
Peso molecular:
62.07
Beilstein/REAXYS Number:
505945
EC Number:
MDL number:
UNSPSC Code:
41116107
eCl@ss:
39020501
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to USP 1265515

vapor density

2.1 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

752 °F

expl. lim.

15.3 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.431 (lit.)

bp

195-198 °C

mp

−13 °C (lit.)

density

1.113 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OCCO

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ethylene glycol can also be produced from fossil fuels (petroleum, natural gas and coal) and biomass-derived resources. It is a polyol having a wide range of industrial applications.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Ethylene glycol may be used as a standard in the determination of ethylene glycol present in serum samples using gas chromatography (GC).

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2089 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Health hazardExclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - STOT RE 2 Oral

target_organs

Kidney

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

239.0 °F - open cup

flash_point_c

115 °C - open cup


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Gas-chromatographic determination of ethylene glycol in serum
Porter H.W and Auansakul aA
Clinical Chemistry, 28, 75-78 (1982)
Peter Mygind Leth et al.
Forensic science international, 155(2-3), 179-184 (2005-10-18)
Ethylene glycol (EG) can be found in many agents, such as antifreeze. Ingestion of EG may cause serious poisoning. Adults are typically exposed when EG is ingested as a cheap substitute for ethanol or in suicide-attempts. Children may be exposed
Yi Wang et al.
Journal of the American Chemical Society, 135(5), 1941-1951 (2013-01-16)
This article describes a robust method for the facile synthesis of small Ag nanocubes with edge lengths controlled in the range of 18-32 nm. The success of this new method relies on the substitution of ethylene glycol (EG)--the solvent most
Andrea Marchionni et al.
ChemSusChem, 6(3), 518-528 (2013-02-14)
The electrooxidation of ethylene glycol (EG) and glycerol (G) has been studied: in alkaline media, in passive as well as active direct ethylene glycol fuel cells (DEGFCs), and in direct glycerol fuel cells (DGFCs) containing Pd-(Ni-Zn)/C as an anode electrocatalyst
Mona Sheikhi et al.
Fertility and sterility, 100(1), 170-177 (2013-04-10)
To study the preservation of follicles within ovarian tissue vitrified using only one or a combination of three permeating cryoprotectants. Experimental study. University hospital. Ovarian tissue was donated by consenting women undergoing elective cesarean section. Ovarian tissue was vitrified in

Chromatograms

suitable for GC

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