G3632

Gentamicina sulfate salt

potency: ≥590 I.U. Gentamicin base per mg

• Sinónimos: GM Sulfate, Gentamicin C
• Número de CAS: 1405-41-0
• EC Number: 215-778-9
• MDL number: MFCD00270181
• UNSPSC Code: 51281651
• eCl@ss: 42020823
• PubChem Substance ID: 329799915
• NACRES: NA.76

Propiedades

• biological source: Micromonospora purpurea
• Quality Level: 200
• form: powder
• potency: ≥590 I.U. Gentamicin base per mg; ≥590 units/mg Gentamicin
• storage condition: (Tightly closed. Dry. )
• concentration: 50 μg/mL in H₂O (is the recommended working concentration for eukaryotic cell culture)
• color: white to off-white
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycoplasma
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[
• InChI: 1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1
• InChI key: RDEIXVOBVLKYNT-HDZPSJEVSA-N

Descripción

General description

Gentamicin sulfate Salt is a broad-spectrum aminoglycoside antibiotic which is derived from Micromonospora purpurea.

Application

Gentamicin sulfate Salt is used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. This product is recommended for use at 50 mg/L. Gentamicin sulfate Salt can be used:

• in the research of the effectiveness of antibiotics against different bacterial cultures
• in the research of neuronal signal processing

Biochem/physiol Actions

Modo de acción: La gentamicina produce un error de lectura de codón al unirse a la subunidad ribosómica 30S y bloquear la translocación del peptidil-ARNt del sitio aceptor al sitio donante. El efecto bactericida de la gentamicina en Pseudomonas aeruginosa se ejerce mediante la unión de la gentamicina a la membrana externa, donde desplaza los cationes naturales, desestabiliza la membrana y forma agujeros en la superficie celular.

Espectro antimicrobiano: Incluye bacterias gramnegativas y grampositivas, entre ellas cepas resistentes a la tetraciclina, el cloranfenicol, la canamicina y la colistina, en particular cepas de Pseudomonas, Proteus, Staphylococcus y Streptococcus.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Components

Freely soluble in water, practically insoluble in ethanol

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.

Storage and Stability

Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-14. [2]

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves