A7085

Acetaminophen

BioXtra, ≥99.0%

• Sinónimos: 4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol
• Fórmula lineal: CH₃CONHC₆H₄OH
• Número de CAS: 103-90-2
• Peso molecular: 151.16
• Beilstein: 2208089
• Número CE: 203-157-5
• Número MDL: MFCD00002328
• Código UNSPSC: 12352111
• ID de la sustancia en PubChem: 24891173
• NACRES: NA.25

Propiedades

• Línea del producto: BioXtra
• Nivel de calidad: 200
• Ensayo: ≥99.0%
• Formulario: powder
• impurezas: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• residuo de ign.: ≤0.1%
• mp: 168-172 °C (lit.)
• solubilidad: ethanol: 0.5 M, clear, colorless
• trazas de anión: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• trazas de catión: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• cadena SMILES: CC(=O)Nc1ccc(O)cc1
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
• Clave InChI: RZVAJINKPMORJF-UHFFFAOYSA-N
• Información sobre el gen: human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

Descripción

Descripción general

Acetaminophen or paracetamol is an analgesic and antipyretic.[1] It is however a weak non opioid analgesic.[2]

Aplicación

Acetaminophen has been used:

• as an anti-inflammatory drug to test its effect in lipid peroxidation in marine mussels[3]
• to test its effect on neurite outgrowth in gamma-aminobutyric acid-ergic and glutamatergic neurons[4]
• as a hepatocellular injury inducing agent in mice[5]

Analgesic.

Acciones bioquímicas o fisiológicas

Acetaminophen or paracetamol is an inhibitor of prostaglandin synthesis. It is complexed with arachidonic acid in central nervous system resulting in the formation of N-arachidonoylphentolamine, which is essential for the activation of cannabinoid receptor.[1] Acetaminophen is metabolized to toxic N-acetyl-p-benzoquinone imine. Paracetamol is prescribed for osteoarthritis pain and inhibits cyclooxygenase 1 and 2 activities.[6] It is metabolized by the cytochrome P450 enzymes in liver and is implicated in liver toxicity.[2]

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 364.3 °F - Pensky-Martens closed cup
• Punto de inflamabilidad (°C): 184.6 °C - Pensky-Martens closed cup
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves