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Merck

33864

Supelco

Tilmicosin

VETRANAL®, analytical standard, mix of isomers

Sinónimos:

20-Deoxo-20-(3,5-dimethyl-1-piperidinyl)desmycosin

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About This Item

Fórmula empírica (notación de Hill):
C46H80N2O13
Peso molecular:
869.13
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC1OC(OCC(C(CC)O2)/C=C(/C=C/C(C(C)CC(CCN3CC(C)CC(C)C3)C(OC4OC(C)C(O)C(N(C)C)C4O)C(C)C(O)CC2=O)=O)C)C(OC)C(OC)C1O

InChI

1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1

InChI key

JTSDBFGMPLKDCD-XVFHVFLVSA-N

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General description

Tilmicosin is a semisynthetic macrolide antibiotic, with broad spectrum activity towards Mycoplasma spp., Pasteurella spp., and various gram-positive organisms in animals.

Application

Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tilmicosin may be used as a reference standard for the determination of the analyte in chicken, swine, cattle, sheep tissues and milk samples using liquid chromatography with ultraviolet detection (LC-UV).

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

target_organs

Cardio-vascular system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)


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Visite la Librería de documentos

Dapeng Peng et al.
Journal of agricultural and food chemistry, 60(1), 44-51 (2011-12-06)
Incorrect use of tylosin and tilmicosin could result in allergy and select resistance. To monitor the illegal use of these antibiotics in animals, a monoclonal-based indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) has been established. Several haptens were synthesized and conjugated
Xinxin Ci et al.
Immunopharmacology and immunotoxicology, 33(4), 626-632 (2011-03-25)
Tilmicosin, a semi-synthetic tylosin-derived macrolide antibiotic commonly used by veterinarians, has been shown to possess anti-inflammatory activity. However, possible use in asthma treatment has not yet been studied. In this study, we investigated the anti-inflammatory properties of tilmicosin using a
Shuyu Xie et al.
Particle and fibre toxicology, 8, 33-33 (2011-11-22)
Our previous studies demonstrated that tilmicosin-loaded hydrogenated castor oil solid lipid nanoparticles (Til-HCO-SLN) are a promising formulation for enhanced pharmacological activity and therapeutic efficacy in veterinary use. The purpose of this work was to evaluate the acute toxicity of Til-HCO-SLN.
Determination of tilmicosin residues in cow and sheep milk by liquid chromatography.
Stobba-Wiley.MC and Readnour.SR
Journal of AOAC (Association of Official Analytical Chemists) International, 83(3), 555-562 (2000)
Meirong Song et al.
Drug development and industrial pharmacy, 37(6), 714-718 (2011-01-06)
The aim of this study was to use silica nanoparticles as the carrier for controlled release of tilmicosin. Tilmicosin was selected as a drug model molecule because it has a lengthy elimination half-life and a high concentration in milk after

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