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Merck

33366

Supelco

Leptophos

PESTANAL®, analytical standard

Sinónimos:

O-(4-Bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate

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About This Item

Fórmula empírica (notación de Hill):
C13H10BrCl2O2PS
Número de CAS:
Peso molecular:
412.07
Beilstein/REAXYS Number:
2152663
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
NMR: suitable
gas chromatography (GC): suitable

mp

71-73 °C

suitability

passes test for identity (NMR)

application(s)

agriculture
environmental

format

neat

storage temp.

2-8°C

SMILES string

COP(=S)(Oc1cc(Cl)c(Br)cc1Cl)c2ccccc2

InChI

1S/C13H10BrCl2O2PS/c1-17-19(20,9-5-3-2-4-6-9)18-13-8-11(15)10(14)7-12(13)16/h2-8H,1H3

InChI key

CVRALZAYCYJELZ-UHFFFAOYSA-N

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General description

Leptophos, an organophosphorus insecticide found to be persistent in the environment, shows neurotoxic effects in humans. Its mode of action for pest control involves the inhibition of acetylcholinesterase enzyme activity.

Application

Leptophos may be used as an analytical reference standard for the quantification of the analyte in vegetables using solid phase micro-extraction coupled with gas chromatography-flame photometric detector (SPME-GC-FPD).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Certificados de análisis (COA)

Lot/Batch Number

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Determination of organophosphorus pesticide residues in vegetables using solid phase micro-extraction coupled with gas chromatography-flame photometric detector.
Sapahin AH, et al.
Arabian Journal of Chemistry, 23(1), 636-641 (2014)
Photodegradation of leptophos.
Riskallah RM, et al.
Bulletin of Environmental Contamination and Toxicology, 23(1), 636-641 (1979)
Effect of phenobarbital on the delayed neurotoxicity of leptophos in hens.
N Konno et al.
Archives of environmental contamination and toxicology, 15(6), 653-659 (1986-11-01)
[Effect of the organophosphorus compounds leptophos and TOCP on creatine kinase activity in hens].
K Katoh et al.
Nihon eiseigaku zasshi. Japanese journal of hygiene, 42(4), 847-857 (1987-10-01)
J E Chambers et al.
Journal of biochemical toxicology, 4(3), 201-203 (1989-01-01)
The oxidative desulfuration of the three phosphorothionate insecticides--chlorpyrifos, chlorpyrifos-methyl, and leptophos--was studied in rat brain and liver. Hepatic microsomes demonstrated activities of 4-28 nmol/g/min, with male activity 2- to 4-fold higher than female activity. Very low desulfuration activity of all

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