573099
STAT3 Inhibitor V, Stattic
STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.
Sinónimos:
STAT3 Inhibitor V, Stattic, 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
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About This Item
Fórmula empírica (notación de Hill):
C8H5NO4S
Número de CAS:
Peso molecular:
211.19
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Ensayo
≥95% (HPLC)
Formulario
solid
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
OK to freeze
protect from light
color
pale yellow
solubilidad
DMSO: 10 mg/mL
ethanol: 5 mg/mL
Condiciones de envío
ambient
temp. de almacenamiento
2-8°C
cadena SMILES
[S]1(=O)(=O)c2c(ccc(c2)[N+](=O)[O-])C=C1
InChI
1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
Clave InChI
ZRRGOUHITGRLBA-UHFFFAOYSA-N
Descripción general
A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
Acciones bioquímicas o fisiológicas
Cell permeable: yes
Primary Target
STAT3
STAT3
Product does not compete with ATP.
Reversible: no
Envase
Packaged under inert gas
Advertencia
Toxicity: Irritant (B)
Reconstitución
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
Otras notas
Schust, J., et al. 2006. Chem. Biol.13, 1235.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órganos de actuación
Respiratory system
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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