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Merck
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Key Documents

539522

Sigma-Aldrich

PKCε Translocation Inhibitor Peptide

The PKCε Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKCε. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sinónimos:

PKCε Translocation Inhibitor Peptide, Protein Kinase Cε Translocation Inhibitor I, EAVSLKPT, PKCε Translocation Inhibitor I, PKCε-RACK2 Interaction Inhibitor I

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About This Item

Fórmula empírica (notación de Hill):
C37H65N9O13
Peso molecular:
843.96
UNSPSC Code:
12352202
NACRES:
NA.77

Quality Level

100

assay

≥97% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 3 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

An octapeptide that selectively inhibits the translocation of PKCε to subcellular sites. Inhibition of PKCε translocation is known to specifically block phorbol ester or norepinephrine-mediated regulation of contraction in cardiomyocytes.
An octapeptide that selectively inhibits the translocation of protein kinase Cε to subcellular sites in a reversible manner. Inhibition of PKCε translocation is known to specifically block phorbol ester- or norepinephrine-mediated regulation of contraction in cardiomyocytes.

Biochem/physiol Actions

Cell permeable: no
Primary Target
PKCε Translocation
Product does not compete with ATP.
Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Yedovitzky, M., et al. 1997. J. Biol. Chem. 272, 1417.
Johnson, J.A., et al. 1996. J. Biol. Chem.271, 24962.

Legal Information

Sold under license of U.S. Patent 5,783,405.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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