444190
MAP Kinase Inhibitor Set II
The MAP Kinase Inhibitor Set II controls the biological activity of MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
form
solid
potency
2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
shipped in
ambient
storage temp.
−20°C
General description
Contains 5 mg of PD 98059 (Cat. No. 513000), 1 mg each of SB 203580 (Cat. No. 559389), and U0126 (Cat. No. 662005), and 1 mg of the negative control, SB 202474 (Cat. No. 559387).
The Mitogen-activated protein kinases (MAP Kinases) are a group of protein serine/threonine kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. MAP kinases, in combination with several other signaling pathways can differentially alter phosphorylation status of the transcription factors that is unique to a given signal from outside the cell. A controlled regulation of these cascades is involved in cell proliferation and differentiation, whereas an unregulated activation of these MAP kinases can result in oncogenesis. Three major types of MAP kinase cascades have been reported in mammalian cells that respond synergistically to different upstream signals. They are ERK1/ERK2 MAP kinases, the JNK/SAPK (c-Jun kinase/stress activated protein kinase), and the p38 kinase.
The Calbiochem MAP Kinase Inhibitor Set II contains 4 inhibitors with different MAP Kinase specificities for your convenience.
The Calbiochem MAP Kinase Inhibitor Set II contains 4 inhibitors with different MAP Kinase specificities for your convenience.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze
(-20°C).
(-20°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
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