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Merck
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Key Documents

07-398

Sigma-Aldrich

Anti-phospho-NR2B (Ser1303) Antibody

Upstate®, from rabbit

Sinónimos:

Anti-DEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_000834

UniProt accession no.

Q13224

shipped in

dry ice

target post-translational modification

phosphorylation (pSer1303)

Gene Information

human ... GRIN2B(2904)
mouse ... Grin2B(14812)
rat ... Grin2B(24410)

Specificity

Recognizes phospho-NR2B.

Immunogen

Peptide corresponding to amino acids 1297-1309 of human phospho-NR2B

Application

Anti-phospho-NR2B (Ser1303) Antibody detects level of phospho-NR2B (Ser1303) & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress

Neurodegenerative Diseases

Quality

routinely evaluated by immunoblot in a rat brain microsomal protein preparation

Target description

~180 kDa

Linkage

Replaces: 04-1148

Physical form

Format: Purified
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Protein A purified

Storage and Stability

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Brain tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Substrate-selective and calcium-independent activation of CaMKII by ?-actinin.
Jalan-Sakrikar, N; Bartlett, RK; Baucum, AJ; Colbran, RJ
The Journal of Biological Chemistry null
C Castillo et al.
Neuroscience, 177, 308-320 (2011-01-11)
The involvement of substance P (SP) in neuronal sensitization through the activation of the neurokinin-1-receptor (NK1r) in postsynaptic dorsal horn neurons has been well established. In contrast, the role of SP and NK1r in primary sensory dorsal root ganglion (DRG)
Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting.
Mori, Hisashi and Mishina, Masayoshi
Life Sciences, 74, 329-336 (2003)
M Sheng et al.
Nature, 368(6467), 144-147 (1994-03-10)
Activation of the N-methyl-D-aspartate (NMDA) receptor is important for certain forms of activity-dependent synaptic plasticity, such as long-term potentiation (reviewed in ref. 1), and the patterning of connections during development of the visual system (reviewed in refs 2, 3). Several
S Strack et al.
The Journal of biological chemistry, 275(31), 23798-23806 (2000-04-15)
Calcium influx through the N-methyl-d-aspartate (NMDA)-type glutamate receptor and activation of calcium/calmodulin-dependent kinase II (CaMKII) are critical events in certain forms of synaptic plasticity. We have previously shown that autophosphorylation of CaMKII induces high-affinity binding to the NR2B subunit of
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