700146P
Avanti
alkyne-cholesterol
27-norcholest-5-en-25-yn-3β-ol, powder
Sinónimos:
alkynyl cholesterol
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About This Item
Fórmula empírica (notación de Hill):
C26H40O
Número de CAS:
Peso molecular:
368.60
Número MDL:
Código UNSPSC:
12352211
NACRES:
NA.25
Productos recomendados
Ensayo
>99% (TLC)
Formulario
powder
envase
pkg of 1 × 100 μg (700146P-100ug)
pkg of 1 × 250 μg (700146P-250ug)
fabricante / nombre comercial
Avanti Research™ - A Croda Brand 700146P
tipo de lípido
click reagents
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
Categorías relacionadas
Descripción general
Alkyne-cholesterol is a clickable cholesterol probe proprietary for Avanti Polar Lipids. They differ from cholesterol by having an alkyne group.
This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry′, in the presence of a copper (Cu)-containing catalyst.
Acciones bioquímicas o fisiológicas
Alkyne-cholesterol is not applicable for use in living cells due to copper ion (Cu (I) and Cu (II)) requirements. It aids in easy and sensitive detection of cholesterol using various biophysical methods. Alkyne-cholesterol can be conjugated to boron-dipyrromethene (BODIPY) fluorescent dye. It is useful in cholesterol trafficking studies in various organelles including mitochondria, endoplasmic reticulum and Golgi.
Envase
5 mL Amber Glass Screw Cap Vial (700146P-100ug)
5 mL Amber Glass Screw Cap Vial (700146P-250ug)
Información legal
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
J Králová et al.
Folia biologica, 65(1), 1-10 (2019-06-07)
Cellular cholesterol plays fundamental and diverse roles in many biological processes and affects the pathology of various diseases. Comprehensive and detailed understanding of the cellular functions and characteristics of cholesterol requires visualization of its subcellular distribution, which can be achieved
Cholesterol: Revisiting its fluorescent journey on 200th anniversary of Chevruel?s ?cholesterine?
Chaudhuri A and Anand D
Biomedical Spectroscopy and Imaging , 6(1-2), 1/24/2020-1/24/2020 (2017)
Katarzyna A Solanko et al.
Lipid insights, 8(Suppl 1), 95-114 (2015-01-01)
Cholesterol transport between cellular organelles comprised vesicular trafficking and nonvesicular exchange; these processes are often studied by quantitative fluorescence microscopy. A major challenge for using this approach is producing analogs of cholesterol with suitable brightness and structural and chemical properties
Katherine Windsor et al.
Journal of lipid research, 54(10), 2842-2850 (2013-07-06)
Lipid modifications aid in regulating (and misregulating) protein function and localization. However, efficient methods to screen for a lipid's ability to modify proteins are not readily available. We present a strategy to identify protein-reactive lipids and apply it to a
Kristina Hofmann et al.
Journal of lipid research, 55(3), 583-591 (2013-12-18)
Cholesterol is an important lipid of mammalian cells and plays a fundamental role in many biological processes. Its concentration in the various cellular membranes differs and is tightly regulated. Here, we present a novel alkyne cholesterol analog suitable for tracing
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