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923834

Sigma-Aldrich

Chitosan-mPEG 1k

25-60% PEGylation, medium MW

Sinónimos:

Medium MW, PEGylated Chitosan

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About This Item

Fórmula lineal:
(C8H13NO5)p((C2H4O)nC10H17NO6)m
UNSPSC Code:
12352201
NACRES:
NA.23

Quality Level

100

form

solid (powder or chunk(s) or fiber)

color

white to off-white

storage temp.

2-8°C

Application

  • Chitosan has in the last decades been widely used in a variety of applications, both industrially and pharmaceutically.
  • Its positive charges under slightly acidic conditions allow it to form complexes or nanoparticles.
  • During the delivery process, the stable compact structure of the complex, with cationic chitosan chains as the outershell and the anionic genes/drugs as the core, efficiently protects genes/drugs from the ″sweeping effect″ of mucociliary clearance and degradation by enzymes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Li Xiang et al.
Physical chemistry chemical physics : PCCP, 21(37), 20571-20581 (2019-08-01)
PEGylation can modify the physicochemical properties of native chitosan and improves its water solubility. PEGylated chitosan has been widely used as a gene/drug delivery vector by forming a polyelectrolyte complex (PEC) in biomedical engineering. The molecular interactions of PEGylated chitosan
PEGylated chitosan derivatives:Synthesis, characterizations and pharmaceutical applications
Casettarietal L, et al.
Progress in Polymer Science, 37, 659-685 (2012)
Peggy Chan et al.
Biomaterials, 28(3), 540-549 (2006-09-27)
Poor water solubility and low transfection efficiency of chitosan are major drawbacks for its use as a gene delivery carrier. PEGylation can increase its solubility, and folate conjugation may improve gene transfection efficiency due to promoted uptake of folate receptor-bearing
H Ragelle et al.
Journal of controlled release : official journal of the Controlled Release Society, 176, 54-63 (2014-01-07)
This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing without cytotoxicity and (ii) stability in biological media including blood. Therefore, the influence of chitosan/tripolyphosphate ratio

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