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912123

Sigma-Aldrich

Trimethyl chitosan

medium molecular weight, degree of quaternization: 40- 60%

Sinónimos:

N,N,N-trimethyl chitosan, Chitosan trimethyl, Mucoadhesive polymers, TMC, TMC Chitosan

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About This Item

Fórmula lineal:
(C9H18ClNO4)n
Número de CAS:
52349-26-5
Número MDL:
MFCD00008176
Código UNSPSC:
12162002
NACRES:
NA.23

Nivel de calidad

100

Formulario

powder

color

light yellow to light brown

temp. de almacenamiento

2-8°C

Categorías relacionadas

Aplicación

Chitosan offers remarkable biological properties, it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Among all the quaternized chitosans, N, N, N-trimethyl chitosan chloride (TMC) is the most widely applied in biomedical applications.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCM0761

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Preparation and Characterization of Particles from Chitosan with Different Molecular Weights and Their Trimethyl Chitosan Derivatives for Nasal Immunization.
BOONYO W, et al.
Journal of Metals, Materials and Minerals, 18(2), 59-65 (2008)
Preparation and NMR characterization of highly substituted IV-trimethyl chitosan chloride.
A B Sieval, et al.
Carbohydrate Polymers, 36, 157-165 (1998)
Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering.
Rieux A D, et al.
Polymer Science (2011)
J H Hamman et al.
Drug development and industrial pharmacy, 29(2), 161-172 (2003-03-22)
N-trimethyl chitosan chloride (TMC) is a polycation that enhances drug transport across epithelia by opening tight junctions. The degree of quaternization of TMC determines the number of positive charges available on the molecule for interactions with the negatively charged sites
Amir K Varkouhi et al.
Bioconjugate chemistry, 21(12), 2339-2346 (2010-11-06)
N,N,N-Trimethylated chitosan (TMC) is a biodegradable polymer emerging as a promising nonviral vector for nucleic acid and protein delivery. In the present study, we investigated whether the introduction of thiol groups in TMC enhances the extracellular stability of the complexes

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