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Merck
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725765

Sigma-Aldrich

2-Methyl-4-isothiazolin-3-one

95%

Sinónimos:

2-Methyl-3(2H)-isothiazolone

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About This Item

Fórmula empírica (notación de Hill):
C4H5NOS
Número de CAS:
2682-20-4
Peso molecular:
115.15
Beilstein:
606203
Número CE:
220-239-6
Número MDL:
MFCD01742315
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
329764182
NACRES:
NA.21

Nivel de calidad

100

Ensayo

≥94.0% (GC)
95%

Formulario

lumps

impurezas

≤5% water

cadena SMILES

CN1SC=CC1=O

InChI

1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3

Clave InChI

BEGLCMHJXHIJLR-UHFFFAOYSA-N

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Aplicación

  • Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide.: This study investigates the differential sensitivity of daphnids to 2-Methyl-4-isothiazolin-3-one, highlighting the biochemical mechanisms underlying these variations. The findings provide crucial insights for environmental safety assessments (Kim et al., 2023).
  • Effects of the biocide methylisothiazolinone on Xenopus laevis wound healing and tail regeneration.: The study assesses the impact of 2-Methyl-4-isothiazolin-3-one on regenerative processes in amphibians, contributing to the understanding of its biological effects and potential toxicity (Delos Santos et al., 2016).
  • T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.: This review includes discussions on 2-Methyl-4-isothiazolin-3-one-induced contact dermatitis, providing valuable information for dermatological applications and safety assessments (Knackstedt and Zug, 2015).

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A

Riesgos supl.

EUH071

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
BCCM9076
BCCM7270
BCCG6210
BCCM6941
BCCL7663

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Christina L Burnett et al.
International journal of toxicology, 29(4 Suppl), 187S-213S (2010-07-22)
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble
Julien Mutschler et al.
Toxicology in vitro : an international journal published in association with BIBRA, 23(3), 439-446 (2009-05-16)
Assessment of skin sensitization hazard of chemicals currently depends on in vivo methods. Considering the forthcoming European Union ban on in vivo testing of cosmetic/toiletry ingredients, the search for alternative non-animal approaches is an urgent challenge for investigators today. For
Michael D Lundov et al.
Contact dermatitis, 69(5), 271-275 (2013-10-15)
The prevalence of contact allergy to the isothiazolinone preservative methylchloroisothiazolinone (MCI) in combination with methylisothiazolinone (MI) and MI alone has increased in the last couple of years. To investigate the prevalence of contact allergy to MI, MCI/MI and benzisothiazolinone (BIT)
Leena Ackermann et al.
Contact dermatitis, 64(1), 49-53 (2010-12-21)
Antimicrobials constitute the second most common cause of contact allergy to cosmetics. Methylisothiazolinone (MI), previously always used together with methylchloroisothiazolinone (MCI), has recently been approved in the EU for use on its own in cosmetics and also various industrial products.
Paula Maio et al.
Cutaneous and ocular toxicology, 31(2), 151-153 (2011-11-05)
Several preservatives are currently allowed in cosmetic products in the EU. However, only a few of them are strongly represented on the market: formaldehyde, parabens, formaldehyde releasers and methylchoroisothiazolinone/methylisothiazolinone (MCI/MI). MCI/MI has been widely used during recent years for the
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