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717436

Sigma-Aldrich

Benzamide oxime

97%

Sinónimos:

N-Hydroxybenzamide

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About This Item

Fórmula empírica (notación de Hill):
C7H8N2O
Número de CAS:
613-92-3
Peso molecular:
136.15
EC Number:
210-361-8
MDL number:
MFCD00474011
UNSPSC Code:
12352100
PubChem Substance ID:
329763488
NACRES:
NA.22

Quality Level

100

assay

97%

form

solid

mp

74-78 °C

functional group

amine
oxime
phenyl

SMILES string

N\C(=N\O)c1ccccc1

InChI

1S/C7H8N2O/c8-7(9-10)6-4-2-1-3-5-6/h1-5,10H,(H2,8,9)

InChI key

MXOQNVMDKHLYCZ-UHFFFAOYSA-N

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCM3112
MKBT6790V
MKBC3660

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B Clement et al.
Molecular pharmacology, 43(3), 335-342 (1993-03-01)
Previous investigations have provided evidence for the participation of the cytochrome P-450 (P-450) enzyme system in the established N-hydroxylation of benzamidine to benzamidoxime by microsomal fractions from rabbit liver homogenates. In the present investigation, a representative mixture of P-450 isoenzymes
B Clement et al.
Chemical research in toxicology, 13(10), 1037-1045 (2000-11-18)
For the reduction of N-hydroxylated derivatives of strongly basic functional groups, such as amidines, guanidines, and aminohydrazones, an oxygen-insensitive liver microsomal system, the benzamidoxime reductase, has been described. To reconstitute the complete activity of the benzamidoxime reductase, the system required
B Clement et al.
Xenobiotica; the fate of foreign compounds in biological systems, 17(6), 659-667 (1987-06-01)
1. A simple and fast h.p.l.c. analysis of benzamidoxime formed by microsomal N-hydroxylation of benzamidine is presented which is well suited for the determination of the N-oxygenation activity of microsomal enzymes. 2. Optimal reaction conditions were determined. The apparent Km
B Clement et al.
The Journal of biological chemistry, 272(31), 19615-19620 (1997-08-01)
Drugs containing strong basic nitrogen functional groups can be N-oxygenated to genotoxic products. While the reduction of such products is of considerable toxicological significance, most in vitro studies have focused on oxygen-sensitive reductase systems. However, an oxygen-insensitive microsomal hydroxylamine reductase
A Jousserandot et al.
Biochemistry, 37(49), 17179-17191 (1998-12-23)
Oxidation by rat liver microsomes of 13 compounds involving a C=N(OH) function (including N-hydroxyguanidines, amidoximes, ketoximes, and aldoximes) was found to occur with the release of nitrogen oxides such as NO, NO2-, and NO3-. The greatest activities were observed with
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