544272
5-Chlorothiophene-2-sulfonyl chloride
96%
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About This Item
Fórmula empírica (notación de Hill):
C4H2Cl2O2S2
Número de CAS:
Peso molecular:
217.09
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Productos recomendados
Quality Level
assay
96%
refractive index
n20/D 1.586 (lit.)
bp
112-117 °C (lit.)
density
1.623 g/mL at 25 °C (lit.)
functional group
chloro
storage temp.
2-8°C
SMILES string
Clc1ccc(s1)S(Cl)(=O)=O
InChI
1S/C4H2Cl2O2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H
Inchi Key
SORSTNOXGOXWAO-UHFFFAOYSA-N
General description
5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride.
Application
5-Chlorothiophene-2-sulfonyl chloride may be used in the preparation of:
- (S)-N-(5-chlorothiophene-2-sulfonyl)-β,β-diethylalaninol
- N-(3-(1H-pyrazol-1-yl)pyridin-2-yl)-5-chlorothiophene-2-sulfonamide
- 5-chloro-4-nitrothiophene-2-sulfonyl chloride
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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C A Hunt et al.
Journal of medicinal chemistry, 37(2), 240-247 (1994-01-21)
3-Aminoalkyl derivatives of thieno[2,3-b][1,4]thiazine-6-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. The compounds described were found to be excellent in vitro inhibitors of carbonic anhydrase II and in vivo to lower intraocular pressure in three rabbit models
A facile stereoselective total synthesis of (S)-N-(5-chlorothiophene-2-sulfonyl)-?,?-diethylalaninol.
Reddy BN and Sing RP.
Der Pharma Chemica, 7(1), 201-205 (2015)
Afjal H Miah et al.
Organic & biomolecular chemistry, 12(11), 1779-1792 (2014-02-12)
A knowledge-based library of aryl 2,3-dichlorophenylsulfonamides was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme. X-ray diffraction studies were used to identify the pyrazole ring as a
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