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333786

Sigma-Aldrich

L-Dopa-(phenyl-d3)

≥98 atom % D, ≥98% (CP)

Sinónimos:

3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine

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About This Item

Fórmula lineal:
(HO)2C6D3CH2CH(NH2)CO2H
Número de CAS:
53587-29-4
Peso molecular:
200.21
MDL number:
MFCD00075014
UNSPSC Code:
12352209
PubChem Substance ID:
24860180
NACRES:
NA.12

isotopic purity

≥98 atom % D

Quality Level

200

assay

≥98% (CP)

form

powder

optical activity

[α]27/D −11.5°, c = 5 in 1 M HCl

technique(s)

mass spectrometry (MS): suitable

mp

292 °C (dec.) (lit.)

mass shift

M+3

storage temp.

2-8°C

SMILES string

[2H]c1c([2H])c(C[C@H](N)C(O)=O)c([2H])c(O)c1O

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1/i1D,2D,4D

InChI key

WTDRDQBEARUVNC-UOCCHMHCSA-N

Categorías relacionadas

General description

L-Dopa-(phenyl-d3) is an isotopic analogue of 3-(3,4-Dihydroxyphenyl)-L-alanine amino acid.

Application

L-Dopa-(phenyl-d3) or (3-(3,4-dihydroxyphenyl-2,5,6-d3)-L-alanine) can be used as an internal standard for the quantification of methyldopa in human plasma by LC-MS-MS based method.
L-Dopa-(phenyl-d3) can be used as an internal standard.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MBBD9009
MBBD9008
MBBD7762
MBBD5985
MBBD5984

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Glauber de S Araujo et al.
PloS one, 7(1), e29561-e29561 (2012-01-19)
Capsule production is common among bacterial species, but relatively rare in eukaryotic microorganisms. Members of the fungal Cryptococcus genus are known to produce capsules, which are major determinants of virulence in the highly pathogenic species Cryptococcus neoformans and Cryptococcus gattii.
Celso H Oliveira et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 768(2), 341-348 (2002-03-13)
A method based on LC-MS-MS is described for the determination of methyldopa in human plasma using dopa-phenyl-D3 as the internal standard. The method has a chromatographic run time of 5.5 min and was linear in the range of 20-5000 ng/ml.
Dario Breitel et al.
Metabolic engineering, 65, 185-196 (2020-11-27)
L-DOPA, also known as Levodopa or L-3,4-dihydroxyphenylalanine, is a non-standard amino acid, and the gold standard drug for the treatment for Parkinson's Disease (PD). Recently, a gene encoding the enzyme that is responsible for its synthesis, as a precursor of
Jeong-Ook Lee et al.
Journal of ginseng research, 42(3), 389-399 (2018-07-10)
The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of
Jing Huo et al.
Molecular medicine reports, 23(1) (2020-11-18)
Vitiligo (VIT) is caused by loss and degradation of functional epidermal melanocytes. Studies have indicated that melanocyte destruction may be associated with an imbalance between regulatory T cells (Treg cells) and effector T cells (Teff cells). The current study aimed to investigate the
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