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Merck

Design and properties of novel gallium-doped injectable apatitic cements.

Acta biomaterialia (2015-06-16)
Charlotte Mellier, Franck Fayon, Florian Boukhechba, Elise Verron, Myriam LeFerrec, Gilles Montavon, Julie Lesoeur, Verena Schnitzler, Dominique Massiot, Pascal Janvier, Olivier Gauthier, Jean-Michel Bouler, Bruno Bujoli
RESUMEN

Different possible options were investigated to combine an apatitic calcium phosphate cement with gallium ions, known as bone resorption inhibitors. Gallium can be either chemisorbed onto calcium-deficient apatite or inserted in the structure of β-tricalcium phosphate, and addition of these gallium-doped components into the cement formulation did not significantly affect the main properties of the biomaterial, in terms of injectability and setting time. Under in vitro conditions, the amount of gallium released from the resulting cement pellets was found to be low, but increased in the presence of osteoclastic cells. When implanted in rabbit bone critical defects, a remodeling process of the gallium-doped implant started and an excellent bone interface was observed. The integration of drugs and materials is a growing force in the medical industry. The incorporation of pharmaceutical products not only promises to expand the therapeutic scope of biomaterials technology but to design a new generation of true combination products whose therapeutic value stem equally from both the structural attributes of the material and the intrinsic therapy of the drug. In this context, for the first time an injectable calcium phosphate cement containing gallium was designed with properties suitable for practical application as a local delivery system, implantable by minimally invasive surgery. This important and original paper reports the design and in-depth chemical and physical characterization of this groundbreaking technology.

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Ácido nítrico, 70%, purified by redistillation, ≥99.999% trace metals basis
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Gallium(III) nitrate hydrate, crystalline, 99.9% trace metals basis
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Acetona, JIS special grade, ≥99.5%
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Gallium, 99.99% trace metals basis
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Acetona, natural, ≥97%
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Acetona, SAJ first grade, ≥99.0%
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Acetona, ≥99%, meets FCC analytical specifications
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Ácido nítrico, ACS reagent, ≥90.0%
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Gallium(III) nitrate hydrate, crystals and lumps, 99.999% trace metals basis
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Gallium, 99.9995% trace metals basis
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Gallium, 99.999% trace metals basis
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Ácido nítrico, 1 M
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Acetona, ≥99.5%, for residue analysis
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Ácido nítrico, 0.1 M
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Acetona, for residue analysis, ≥99.5%
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Allyl methyl sulfone, 96%
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Acetona, suitable for HPLC, ≥99.9%
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Acetona, for chromatography, ≥99.8%
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Nitric-14N acid solution, ~10 N in H2O, 99.99 atom % 14N
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Ácido nítrico, SAJ first grade, 65.0-66.0%, density: 1.40
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Acetona, for residue analysis, JIS 5000
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Acetona, suitable for HPLC