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Merck

73033AST

Supelco

Astec® CHIRALDEX G-TA Capillary GC Column

L × I.D. 30 m × 0.25 mm, df 0.12 μm

Sinónimos:

GC column, chiral, gamma-dextran

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About This Item

Código UNSPSC:
41115710
NACRES:
SB.54

Materiales

fused silica

Nivel de calidad

descripción

GC capillary column

envase

pkg of 1 ea

Parámetros

-10-180 °C temperature (isothermal or programmed)

Valor Beta

500

df

0.12 μm

técnicas

gas chromatography (GC): suitable

L × D.I.

30 m × 0.25 mm

grupo activo de la matriz

non-bonded; 2,6-di-O-pentyl-3-trifluoroacetyl derivative of γ-cyclodextrin phase

aplicaciones

agriculture
chemicals and industrial polymers
cleaning products
clinical
cosmetics
environmental
flavors and fragrances
food and beverages
forensics and toxicology
life science and biopharma
personal care
pharmaceutical (small molecule)

tipo de columna

capillary chiral

técnica de separación

chiral

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Descripción general

Astec® CHIRALDEX G-TA is the first choice in the Group 1 CSPs (Surface Interactions, Complex Derivatives). This phase has been shown to be the most broadly-selective phase for the pharmaceutical industry, especially for the analysis of chiral intermediates and drug studies in various stages of clinical trials. Separations occur without the inclusion mechanism and are typically faster and more efficient than most chiral stationary phases. G-TA has also been used to separate parent drug enantiomers and their metabolites. G-TA has its highest selectivity for oxygen-containing analytes like alcohols, diols and polyols as the free alcohol and as an acyl derivative; amines as acyl derivatives; amino alcohols, halogens (Cl>Br>F), amino acids, hydroxy acids, lactones, furans and pyrans. It is also highly selective for halogenated compounds.

Aplicación

Astec® CHIRALDEX G-TA (2,6-di-O-pentyl-3-trifluoroacetyl-γ-cyclodextrin) derivatized cyclodextrin chiral stationary phase may be used in capillary gas chromatography for separation of four isomers from 7 racemic sulfinate esters. It was used in an experimental study done for cloning and characterization of three epoxide hydrolases identified by analyzing open reading frames (ORFs) of a marine bacterium, Erythrobacter litoralis HTCC2594. It was also used in HPLC and GC analyses of the conversion of epoxides during enantioselectivity of epoxide hydrolase from Agrobacterium radiobacter (EchA) using error-prone PCR and DNA shuffling.

Resistencia química o física

Temp. Limits:
  • -10 °C to 180 °C isothermal and programmed

Otras notas

We offer a variety of chromatography accessories including analytical syringes

Información legal

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIRALDEX is a trademark of Sigma-Aldrich Co. LLC

Aplicación

Referencia del producto
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Certificados de análisis (COA)

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Bert van Loo et al.
Chemistry & biology, 11(7), 981-990 (2004-07-24)
The enantioselectivity of epoxide hydrolase from Agrobacterium radiobacter (EchA) was improved using error-prone PCR and DNA shuffling. An agar plate assay was used to screen the mutant libraries for activity. Screening for improved enantioselectivity was subsequently done by spectrophotometric progress
Jung-Hee Woo et al.
Applied microbiology and biotechnology, 76(2), 365-375 (2007-06-02)
Previously, we reported that ten strains belonging to Erythrobacter showed epoxide hydrolase (EHase) activities toward various epoxide substrates. Three genes encoding putative EHases were identified by analyzing open reading frames of Erythrobacter litoralis HTCC2594. Despite low similarities to reported EHases
Catalytic asymmetric synthesis of Japonilure and its enantiomer
Xu, Hao, et al.
Tetrahedron Asymmetry, 25 (20-21), 1372-1375 (2014)
Asymmetric ring opening of meso-epoxides with B-halobis(2-isocaranyl)boranes 2-dIcr2BX
Roy, Chandra D., Brown, Herbert C.
Tetrahedron Asymmetry, 17 (13), 1931-1936 (2006)
Kinetic resolutions concentrate the minor enantiomer and aid measurement of high enantiomeric purity.
Caron, Gaetan; Tseng, George W.M.; Kazlauskas, R.J.
Tetrahedron Asymmetry, 5 (1), 83-92 (1994)

Artículos

Chromatographic enantiomeric separation of amino acids, like proline, is described for chiral GC analysis after derivatization.

Chromatographic enantiomeric separation of amino acids, like proline, is described for chiral GC analysis after derivatization.

Chromatographic enantiomeric separation of amino acids, like proline, is described for chiral GC analysis after derivatization.

Chromatographic enantiomeric separation of amino acids, like proline, is described for chiral GC analysis after derivatization.

Chromatograms

suitable for GCsuitable for GCsuitable for GCsuitable for GCMostrar más

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