SRP4011
Cardiotrophin-1 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Sinónimos:
CT1, CTF1, Cardiophin 1
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About This Item
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥98% (HPLC)
≥98% (SDS-PAGE)
Formulario
lyophilized
mol peso
~22.5 kDa
envase
pkg of 10 μg
condiciones de almacenamiento
avoid repeated freeze/thaw cycles
impurezas
endotoxin, tested
Nº de acceso NCBI
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... CTF1(1489)
Descripción general
Cardiotrophin-1 belongs to the interleukin-6 (IL-6) family of cytokines. It is a cytoprotective protein. The gene is mapped to human chromosome 16p11.
Recombinant human Cardiotrophin-1 is a 22.5kDa protein containing 200 amino acid residues.
Recombinant human Cardiotrophin-1 is a 22.5kDa protein containing 200 amino acid residues.
Acciones bioquímicas o fisiológicas
Cardiotrophin-1 signals via β receptor glycoprotein 130 (gp130) and β receptor leukemia inhibitory factor receptor (LIFR). It confers protective role on cardiac myocytes. Cardiotrophin-1 protects cardiomyocytes from cell death, however, it can also induce cardiac hypertrophy. It is also involved in neural tissue development and helps in protection of the mature nervous system from injuries and dysfunction. Cardiotrophin-1 also protects liver against injury. It is also involved in the control of body weight and intermediate metabolism. In mouse model, it protects β cells from apoptosis. It also promotes glucose-mediated insulin secretion. Absence of the cardiotrophin-1 gene in mice is associated with obesity, hyperglycemia, hyperinsulinemia and hypercholesterolemia.
Forma física
Sterile filtered and then lyophilized in 1 x PBS.
Reconstitución
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 20 mM Tris, pH 8.0 to a concentration of <1.0 mg/mL. The solution can be diluted into other aqueous buffers.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Cardiotrophin-1: A multifaceted cytokine.
Lopez-Yoldi M, et al.
Cytokine & Growth Factor Reviews, 26, 523-523 (2015)
Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals.
Hung HC, et al.
Scientific Reports, 5, 17438-17438 (2015)
Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity.
Lutz SZ, et al.
PLoS ONE, 9, e100391-e100391 (2014)
Alejandro Aranda et al.
Cellular and molecular life sciences : CMLS, 71(23), 4637-4651 (2014-05-06)
We report a new method to generate high-expressing mammalian cell lines in a quick and efficient way. For that purpose, we developed a master cell line (MCL) containing an inducible alphavirus vector expressing GFP integrated into the genome. In the
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