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Merck

SML0493

Sigma-Aldrich

T16Ainh-A01

≥95% (HPLC)

Sinónimos:

2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide

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About This Item

Fórmula empírica (notación de Hill):
C19H20N4O3S2
Número de CAS:
Peso molecular:
416.52
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O

InChI

1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)

InChI key

QSIYTNYMBWYHAA-UHFFFAOYSA-N

Application

T16Ainh-A01 has been used as an inhibitor of transmembrane protein 16A (TMEM16A).

Biochem/physiol Actions

T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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TMEM16A regulates portal vein smooth muscle cell proliferation in portal hypertension.
Zeng X, et al.
Experimental and Therapeutic Medicine, 15(1), 1062-1068 (2018)
Jinyu Zhang et al.
International journal of molecular sciences, 23(22) (2022-11-27)
Dry eye disease (DED) is a multifactorial disease with an incidence of approximately 50% worldwide. DED seriously affects quality of life and work. The prevalence of environmental DED (eDED) ranges from 35 to 48%. Conjunctival fluid secretion dysfunction may be

Artículos

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We offer many products related to chloride channels for your research needs.

We offer many products related to chloride channels for your research needs.

We offer many products related to chloride channels for your research needs.

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