SAB5500151
Anti-Neutrophil Elastase antibody, Rabbit monoclonal
clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
recombinante
expressed in proprietary host
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
SP203, monoclonal
reactividad de especies
human (tested)
técnicas
immunohistochemistry: 1:100
isotipo
IgG
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... ELANE(1991)
Descripción general
Neutrophil elastase (NE) is a monomeric protein, encoded by the gene mapped to human chromosome 19p13.3. The protein has a molecular mass of 25 kDa and is mainly present in the neutrophil granules (located in the neutrophil cytoplasm).
Neutrophil elastase is a serine proteinase synthesized by promyelocytes and promonocytes. It is secreted by neutrophils to degrade extracellular matrix, and to destroy bacteria. It is used as a marker for myeloid leukemia cells.
Inmunógeno
Synthetic peptide from human neutrophil elastase protein.
Acciones bioquímicas o fisiológicas
Neutrophil elastase (NE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. The encoded protein catalyzes the cleavage of tyrosyl-tRNA synthetase to produce cytokine domains that stimulates neutrophil chemotaxis. In addition, NE also facilitates the secretion of the neutrophil chemoattractant, interleukin-8 from endothelial cells.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis
Horwitz M, et al.
Nature Genetics, 23(4), 433-433 (1999)
Franz von Nussbaum et al.
ChemMedChem, 11(2), 199-206 (2015-09-04)
Human neutrophil elastase (HNE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. Overshooting high HNE activity is the consequence of a disrupted protease-antiprotease balance. Accordingly, there has been an intensive search for potent
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