SAB5200022

Monoclonal Anti-CACNA1D antibody produced in mouse

clone S48A-9, 1 mg/mL, purified immunoglobulin

• Sinónimos: Anti-CACH3, Anti-CACN4, Anti-CACNA 1D, Anti-CACNL1A2, Anti-Cav1.3, S48A-9, Anti-oltage dependent L type calcium channel subunit alpha 1D
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: S48A-9, monoclonal
• Formulario: buffered aqueous glycerol solution
• mol peso: antigen predicted mol wt 250 kDa
• reactividad de especies: human, rat, mouse
• concentración: 1 mg/mL
• técnicas: immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• isotipo: IgG2aκ
• Nº de acceso NCBI: NP_058994.1
• Nº de acceso UniProt: Q01668
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: rat ... Cacna1d(29716)

Descripción

Descripción general

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is expressed in many tissues and possesses six transmembrane segments, along with a loop lining the pore of the channel. The gene encoding CACNA1D is localized on human chromosome 3p14.3.

Especificidad

Detects ~250 kDa. No cross-reactivity against Cav1.2

Inmunógeno

Fusion protein amino acids 859-875 of rat Cav1.3, Accession Number P27732

Aplicación

Monoclonal Anti-CACNA1D antibody produced in mouse has been used in immunocytochemistry.

Acciones bioquímicas o fisiológicas

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is crucial for the functioning of the brain and in hearing. It gets activated at a fast rate and withstands high inward Ca²⁺ currents even at threshold voltages. CACNA1D aids in dendritic signals linked to mitochondrial stress in the brain and is important for estrogen-stimulated Ca²⁺ influx. Studies have shown that in atrial myocytes, the C terminus of the channel translocates to the nucleus and regulates Ca²⁺-activated K⁺ channels. CACNA1D was shown to be upregulated in endometrial cancer and its knockdown showed a reduction in cell proliferation in vitro. Mutations in the gene encoding it has been associated with aldosterone-producing adenomas (APAs), where it leads to the formation of small adenomas.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable