SAB4500662

Anti-Aggrecan (Cleaved-Asp³⁶⁹), N-Terminal antibody produced in rabbit

affinity isolated antibody

• Sinónimos: CSPCP, CSPG1, aggrecan core protein, cartilage-specific proteoglycan core protein, chondroitin sulfate proteoglycan core protein 1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 44 kDa
• reactividad de especies: human, rat
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Nº de acceso NCBI: P16112
• Nº de acceso UniProt: P16112
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: proteolytically cleaved (Asp369)
• Información sobre el gen: human ... ACAN(176)

Descripción

Descripción general

Anti-Aggrecan (Cleaved-Asp³⁶⁹) Antibody detects endogenous levels of fragment of activated Aggrecan (Cleaved-Asp³⁶⁹) protein.

Aggrecan is a large aggregating chondroitin sulfate proteoglycan of the human cartilage. It is encoded by AGC1 (aggrecan) gene. It is located on human chromosome 15q26.1.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human Aggrecan.

Immunogen Range: 320-369

Aplicación

Anti-Aggrecan (Cleaved-Asp369), N-Terminal antibody has been used in western blotting[1][2] and immunostaining.

Acciones bioquímicas o fisiológicas

Mutations in aggrecan results in autosomal dominant short stature with accelerated skeletal maturation. Mutation in the variable repeat region of the aggrecan gene (AGC1) leads to spondyloepiphyseal dysplasia.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable