SAB1403982

Monoclonal Anti-INS antibody produced in mouse

clone 7C8, purified immunoglobulin, buffered aqueous solution

• Sinónimos: ILPR, IRDN
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 7C8, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~1.65 kDa
• species reactivity: human
• technique(s): indirect ELISA: suitable
• isotype: IgG3κ
• NCBI accession no.: NM_000207
• UniProt accession no.: P01308
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... INS(3630)

Descripción

General description

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5′ region and with the IGF2 gene at the 3′ region. (provided by RefSeq)

Immunogen

KLH-conjugated human Proinsulin peptide (NP_000198, 48 a.a. ~ 62 a.a)

Sequence
CFFYTPKTRREAEDLQ

Physical form

Solution in phosphate buffered saline, pH 7.4

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable