S6949

β-Synuclein V70M histidine-tagged human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

• Sinónimos: SNCB
• Número MDL: MFCD08705537
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• recombinante: expressed in E. coli
• Nivel de calidad: 200
• Ensayo: ≥90% (SDS-PAGE)
• Formulario: lyophilized powder
• Nº de acceso UniProt: Q16143
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... SNCB(6620)

Descripción

Acciones bioquímicas o fisiológicas

Acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein.

Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missense mutations in neurodegeneration stimulation.

Forma física

Lyophilized from a 0.2 μm filtered solution.

Reconstitución

Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at −20 °C.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)