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Merck
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Key Documents

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S0193

Sigma-Aldrich

SKF-86002

≥98% (HPLC), solid

Sinónimos:

6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole

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About This Item

Fórmula empírica (notación de Hill):
C16H12N3FS
Número de CAS:
72873-74-6
Peso molecular:
297.35
MDL number:
MFCD00869367
UNSPSC Code:
12352200
PubChem Substance ID:
24724598
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white

mp

189-190 °C (lit.)

solubility

DMSO: soluble >10 mg/mL

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4

InChI

1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

InChI key

YOELZIQOLWZLQC-UHFFFAOYSA-N

Gene Information

human ... IL1B(3553) , TNF(7124)
rat ... Alox5(25290)

Biochem/physiol Actions

p38 MAP kinase inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Gerd Wagner et al.
Medicinal research reviews, 26(1), 1-62 (2005-11-12)
The recent successful introduction of the anti-cytokine biologicals Etanercept, Infliximab, Adalimumab, and Anakinra has stimulated the search for anti-cytokine small-molecules. A number of molecular targets have been identified for the development of such small molecular anti-cytokine agents. The focus of
J C Lee et al.
Immunopharmacology, 47(2-3), 185-201 (2000-07-06)
Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed dramatically. The key advances include (1) identification of p38 MAP kinase homologs and protein kinases that act upstream and downstream from p38 MAP kinase
S Su et al.
BioTechniques, 22(6), 1107-1113 (1997-06-01)
We have developed a high-throughput, multiplex reverse transcription PCR (RTPCR) assay that is suitable for the analysis of medium-to low-copy cellular RNA transcripts from small numbers of cells (10(4)). High throughput was attained by utilizing microplate-based RNA extraction and RTPCR
T Ishizuka et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6358-6363 (1997-06-10)
Mast cells synthesize and secrete specific cytokines and chemokines which play an important role in allergic inflammation. Aggregation of the high-affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) in MC/9 mouse mast cells stimulates the synthesis and secretion of tumor
H Watanabe et al.
The Journal of biological chemistry, 276(17), 14466-14473 (2001-03-30)
In chondrogenesis, members of the transforming growth factor-beta (TGF-beta) superfamily play critical roles by inducing gene expression of cartilage-specific molecules. By using a chondrogenic cell line, ATDC5, we investigated the TGF-beta-mediated signaling pathways involved in expression of the aggrecan gene
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